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At Genesis Lifestyle Medicine in Los Angeles, we offer Zepbound® (tirzepatide) as part of our physician-led weight loss programs. This innovative medication is designed to support individuals in achieving long-term weight management by addressing metabolic functions that influence appetite and fat storage. Our medical team delivers in-person care to create customized strategies that promote both physical health and confidence from the inside out.

Experience Up to 20% Weight Reduction*

Zepbound is an FDA-approved prescription treatment indicated for adults who are classified as obese, or for those who are overweight and managing a related health condition such as high blood pressure or type 2 diabetes. It works by mimicking the action of naturally occurring gut hormones that help regulate hunger and insulin activity. 

When combined with lifestyle adjustments—including nutritious eating and regular exercise—Zepbound has been shown in clinical studies to support weight loss of up to 20%.*

In Los Angeles, we provide in-person consultations to determine whether Zepbound is suitable for your weight loss journey and monitor your progress closely to optimize results over time.

Key Advantages of Zepbound

  • May reduce appetite and limit cravings
  • Helps facilitate sustained weight loss
  • Engages natural hormone receptors to improve metabolic health
  • Encourages early satiety during meals
  • Supports healthy blood sugar and insulin regulation
  • Can contribute to lowering risks associated with cardiovascular and metabolic diseases
  • FDA-approved and clinically validated
  • Administered weekly via a simple injection
  • Prescribed in person by qualified healthcare professionals
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What Side Effects Should You Know About?

While Zepbound is generally well tolerated, some individuals may experience side effects. Commonly reported ones include:

  • Nausea
  • Diarrhea
  • Vomiting
  • Constipation
  • Abdominal discomfort
  • Indigestion
  • Redness or irritation at the injection site
  • Tiredness
  • Allergic reactions
  • Gas or bloating
  • Hair thinning
  • Heartburn

Zepbound is not recommended for individuals with a personal or family history of medullary thyroid carcinoma (MTC) or those diagnosed with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). Please visit the official safety information for a full list of potential risks.

How Zepbound Works to Support Weight Loss

Zepbound acts by activating GLP-1 and GIP receptors—two gut-derived hormones responsible for appetite control and glucose metabolism. These hormones send signals to the brain that increase feelings of fullness, slow digestion, and reduce food intake.

This dual-action mechanism may lead to decreased hunger, enhanced satisfaction with smaller meals, and better regulation of blood sugar—especially helpful for individuals with insulin resistance or prediabetes. By influencing multiple biological pathways, Zepbound offers a powerful approach to supporting gradual and sustainable weight reduction.

What to Expect with Zepbound in Los Angeles

Your journey with Zepbound at Genesis Lifestyle Medicine begins with a comprehensive, in-person evaluation in our Los Angeles clinic. Our team will assess your health history, weight loss challenges, and relevant lab results to determine if Zepbound aligns with your needs.

Once prescribed, you’ll receive detailed instructions on how to administer the medication using a prefilled injection pen, typically applied once weekly in the thigh or abdomen. The dosage starts at a lower level and increases as tolerated, allowing your body to adjust while minimizing side effects—all with the supervision of our dedicated providers.

Does Insurance Cover Zepbound?

Insurance coverage for Zepbound varies. While some commercial insurance plans include it, they may require prior authorization. In some cases, Medicare may also offer coverage for specific conditions. Our team in Los Angeles can help review your plan and explore financial options to make treatment accessible.

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Are You a Candidate for Zepbound?

Zepbound might be suitable if you:

  • Have a BMI of 30 or greater (obesity)
  • Have a BMI of 27 or higher with conditions like type 2 diabetes
  • Struggle with ongoing weight gain or weight loss resistance
  • Prefer a non-surgical solution to manage weight
  • Are open to making lasting lifestyle improvements
  • Have no history of thyroid cancer or MEN 2 syndrome

Clinical Results: What the Studies Show*

In a 72-week clinical study of adults without diabetes:

  • A 5 mg dose of Zepbound resulted in average weight loss of 15% (34 lbs)
  • A 10 mg dose led to 19.5% (44 lbs)
  • A 15 mg dose supported 20.9% (48 lbs)
  • Participants using a placebo saw an average loss of 3.1% (7 lbs)

As always, individual outcomes will vary, and it’s important to consult a qualified provider to determine your personal response to treatment.

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Zepbound FAQs

When will I start noticing changes?

Most individuals begin to experience weight loss within several weeks, especially when paired with a healthier diet and regular exercise. Substantial changes are usually observed after 8 to 12 weeks.

Is Zepbound safe?

Zepbound has undergone rigorous clinical testing and is FDA-approved. While it is considered safe for most adults, side effects can occur. Always discuss your full health history with our team, and report any symptoms that persist or worsen. You can also review full safety details here.

How is Zepbound taken?

Zepbound is injected once per week using a prefilled pen. The injection site should be rotated—between the abdomen, thigh, and upper arm—to reduce irritation.

What if I forget to take a dose?

You can take a missed dose within four days (96 hours) of your scheduled injection. If more time has passed, wait until your next regular dose. Never take two doses within a three-day period.

Start Your Zepbound Journey in Los Angeles

At Genesis Lifestyle Medicine in Los Angeles, we’re here to help you discover if Zepbound is the right tool for your weight loss journey. With compassionate, experienced care and tailored treatment plans, we focus on supporting your goals with personalized strategies that evolve with your progress. Book your consultation today to learn more.

*Individual results vary. In a 72-week Zepbound (tirzepatide) study of adults without diabetes, average weight loss was 15.0% (34 lbs.) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs.) for 15 mg, and 3.1% (7 lbs.) for placebo. In a 72-week Zepbound (tirzepatide) study of adults with diabetes, average weight loss was 12.8% (28 lbs.) for 10 mg, 14.7% (33 lbs.) for 15 mg, and 3.2% (7 lbs.) for placebo.

Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4. https://pubmed.ncbi.nlm.nih.gov/35658024

The information provided on this website is not a substitute for professional medical advice. Always consult with a qualified healthcare provider for any questions about your health or treatment.

Zepbound® is a registered trademark of Eli Lilly and Company. This website is not affiliated with, endorsed by, or sponsored by Eli Lilly and Company. All trademarks and brand names are property of their respective owners. Use of these names, logos, and brands does not imply endorsement Genesis Lifestyle Medicine. Information about Zepbound is sourced from publicly available materials and is intended for educational and informational purposes only. All rights to such content belong to the respective company.

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