You wake up after a full night’s sleep, but your body feels like it’s still running on empty. Tasks you used to breeze through now feel exhausting. Your mind feels foggy, your mood isn’t quite the same, and you notice that even minor colds seem to linger longer than before. These subtle yet persistent changes can sometimes be explained by one hidden factor: low NAD+ levels.

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every cell of your body that plays a role in energy production, cellular repair, and healthy aging. When NAD+ levels decline, as they naturally do with age, the effects can be felt across multiple areas of your life. At Genesis Lifestyle Medicine, we help patients identify and address low NAD+ through comprehensive care. Here’s how to recognize the signs and take action.

5 signs of low NAD+ levels

1. Persistent fatigue

Even with adequate rest, you may find yourself battling constant exhaustion if your NAD+ levels are low. This coenzyme is central to mitochondrial energy production, turning the food you eat into usable energy for your cells. Without enough NAD+, your energy output drops significantly, leaving you feeling drained, sluggish, and unmotivated. You might notice difficulty sustaining focus during the day, an increased reliance on caffeine, or a stronger urge to nap.

2. Frequent brain fog

Brain fog can appear as confusion, forgetfulness, or difficulty processing information. NAD+ is essential for supporting neurotransmitter activity and protecting brain cells from damage. When levels decline, communication between neurons becomes less efficient, which can slow down mental processing and memory recall. You may struggle to concentrate during meetings, forget names or tasks more often, or feel mentally “cloudy” even after rest.

3. Slower recovery from exercise or illness

Low NAD+ levels can significantly slow your body’s ability to recover from physical strain, injury, or illness. This coenzyme is involved in DNA repair and tissue regeneration, helping damaged cells heal faster. When NAD+ is lacking, recovery processes are delayed, leading to prolonged soreness after workouts, slower healing from cuts or bruises, and extended symptoms from common colds or infections. Over time, this can reduce your overall resilience.

4. Mood swings or unexplained irritability

Your mood is closely tied to brain chemistry, and NAD+ plays a crucial role in producing and regulating neurotransmitters like serotonin. Low levels can disrupt these pathways, contributing to mood instability, irritability, anxiety, or feelings of sadness without clear triggers. You might find yourself reacting more sharply to minor frustrations or struggling to feel joy in activities you normally enjoy. These shifts can impact relationships and overall emotional well-being.

5. Weakened immune function

NAD+ is vital for healthy immune cell function and inflammation regulation. When your NAD+ levels are low, the immune cells become less effective at fighting off infections and controlling inflammation. This can leave you prone to catching colds, experiencing lingering symptoms, or developing chronic inflammatory conditions. You may notice that illnesses last longer than they used to, cuts or wounds heal more slowly, or seasonal allergies feel more severe.

Tips to optimize NAD+ levels:

• Incorporate NAD+ precursor-rich foods: Your body can synthesize NAD+ from certain nutrients, so eating foods high in precursors can help maintain healthy levels. Add lean poultry, fish, dairy, mushrooms, green vegetables, and whole grains to your diet. These foods contain tryptophan, niacin, and other compounds that can support NAD+ levels.
• Exercise regularly: Consistent physical activity can naturally boost NAD+ levels by stimulating mitochondrial biogenesis, the creation of new mitochondria, and enhancing energy efficiency in cells. Even moderate exercises like brisk walking, swimming, or cycling for 30 minutes a day can contribute to improved cellular health over time.

• Prioritize quality sleep: Your body uses sleep to repair and restore cellular systems, including processes regulated by NAD+. Aim for 7 to 9 hours of quality sleep each night, and maintain a consistent bedtime routine. Minimizing late-night screen use and optimizing your sleep environment can further enhance restorative rest.
• Reduce alcohol consumption: Alcohol metabolism consumes NAD+, which can accelerate depletion if intake is frequent or heavy. Cutting back on alcohol allows your body to preserve more NAD+ for critical cellular functions, helping you maintain energy and resilience.
• Consider NAD+ therapy: If lifestyle changes alone aren’t enough, NAD+ therapy can directly replenish your body’s supply for faster, more noticeable benefits. At Genesis, we offer advanced NAD+ treatments to support energy production, brain function, and healthy aging. We ensure you receive the right dosage and delivery method for your needs.

Low NAD+ levels can impact everything from your energy to your immunity, but recognizing the signs early gives you the power to take control. By making targeted lifestyle changes and, when appropriate, supplementing with NAD+ therapy, you can restore cellular vitality.

At Genesis Lifestyle Medicine, we specialize in helping patients optimize their NAD+ levels through a combination of science-backed treatments and individualized care. With the right support, you can reclaim your energy, sharpen your focus, and protect your health. Contact us today to schedule your consultation!