If you’ve started NAD+ therapy, you already know it’s one of the most powerful ways to support energy production, DNA repair, and overall cellular health. But here’s something you might not realize: pairing NAD+ with the right supplements can boost your energy even further, enhance brain function, reduce inflammation, and protect your cells from damage.
At Genesis Lifestyle Medicine, we focus on helping you heal from the inside out. That means giving your body not just NAD+, but the supporting nutrients it needs to work at its best. Below, we highlight six of the most effective supplements to pair with NAD+ therapy and how they can help you get even better results.
Vitamin B complex
B vitamins, especially vitamin B3 (niacin), are crucial for NAD+ production in your body. When you take NAD+ therapy, giving your cells extra B vitamins ensures they have the raw materials to sustain optimal NAD+ levels. Vitamin B12 supports nerve function, B6 aids neurotransmitter production, and the full B-complex improves energy metabolism, brain performance, and cellular repair. This helps maintain steady energy and mental clarity throughout the day.
Resveratrol
Found naturally in red grapes, berries, and peanuts, resveratrol is a potent antioxidant that works hand in hand with NAD+. It activates sirtuins, which are proteins that regulate cellular health and longevity, allowing NAD+ to work efficiently in supporting DNA repair and reducing age-related decline. When paired with NAD+, resveratrol strengthens your body’s defenses against oxidative stress, helps slow cellular aging, and promotes cardiovascular health.
Coenzyme Q10 (CoQ10)
CoQ10 is another coenzyme essential for mitochondrial energy production. It helps your cells convert nutrients into ATP, the form of energy your body naturally uses. NAD+ therapy improves mitochondrial efficiency, but adding CoQ10 provides even more support for sustained energy, heart health, and reduced fatigue. This is particularly beneficial for active individuals or anyone who experiences low energy due to stress, aging, or chronic illness.
Magnesium
Magnesium is involved in over 300 enzymatic reactions, including those that require NAD+. It supports muscle relaxation, nerve signaling, and energy production, making it a key partner in maximizing NAD+ benefits. Without enough magnesium, your body can’t fully utilize NAD+, which means you might not experience its full effects. Pairing the two can enhance muscle recovery, improve sleep quality, and support a healthy nervous system.
Omega-3 fatty acids
Omega-3s, especially EPA and DHA, are essential fats that your body cannot produce on its own. They help reduce inflammation, improve cognitive function, and protect your brain from age-related decline. When combined with NAD+, omega-3 fatty acids can amplify mental clarity, memory, and mood balance, while also supporting heart and joint health. A high-quality fish oil or algae-based supplement can ensure you get enough of these beneficial fats.
Alpha-lipoic acid (ALA)
ALA is a powerful antioxidant that regenerates other antioxidants like vitamin C and vitamin E. It also plays a role in glucose metabolism and protects cells from oxidative damage. When paired with NAD+, ALA enhances detoxification, supports liver function, and provides an extra layer of defense against free radicals. This combination is ideal if you want to improve overall cellular resilience and slow the effects of aging.
Additional tips to optimize your NAD+ results
Follow a nutrient-rich diet
Focus on whole, unprocessed foods that supply antioxidants, lean proteins, healthy fats, and NAD-boosting nutrients like leafy greens, whole grains, nuts, and seeds. These foods help your body maintain optimal cellular function, reduce inflammation, and provide the raw materials needed for energy production, making NAD+ therapy even more effective over time.
Exercise regularly
Incorporating consistent physical activity, whether it’s strength training, cardio, or even brisk walking, improves cardiovascular health, enhances muscle tone, and stimulates your own NAD+ production. Exercise also boosts mitochondrial efficiency, which works with NAD+ to improve stamina, energy, and overall vitality while reducing the risk of age-related decline.
Prioritize quality sleep
Your body performs its most intensive cellular repair and energy restoration during deep sleep. Prioritizing 7 to 9 hours of restful sleep each night supports hormonal balance, immune function, and NAD+ absorption. Maintaining a regular sleep schedule and creating a calm nighttime routine can dramatically improve the overall benefits of your wellness treatment.
Stay hydrated
Water is essential for nutrient transport, detoxification, and maintaining the electrolyte balance needed for cellular function. Proper hydration ensures NAD+ can work efficiently in supporting energy metabolism and repair processes. Aim for consistent fluid intake throughout the day, and include electrolyte-rich sources if you’re active or live in a hot climate.
Consider professional guidance
A qualified healthcare provider can help tailor your NAD+ therapy and supplement routine to match your individual health goals, lifestyle, and medical history. This ensures you’re using the right doses, avoiding interactions, and combining nutrients effectively for maximum results, safety, and long-term wellness improvements without unnecessary guesswork.
At Genesis Lifestyle Medicine, we believe wellness isn’t about a single treatment; it’s about creating the right conditions for your body to thrive. Pairing NAD+ with targeted supplements can give you more energy, protect your cells, and help you feel your absolute best. Schedule your consultation to explore your supplementation options to pair with NAD+ therapy.
