Antidepressant medications can be life-changing when it comes to managing depression and anxiety, but they can also bring unexpected side effects. Many men notice changes in sexual desire, difficulty maintaining erections, or even a complete loss of arousal.
At Genesis Lifestyle Medicine, we understand how closely mental and sexual health are connected. Our goal is to help you feel balanced, both emotionally and physically. One of the most effective regenerative solutions we offer for men struggling with erectile performance due to antidepressant use is the P-Shot, a natural therapy that can rejuvenate sexual function from within. Let’s explore how antidepressants affect your body, and how the P-Shot may help restore your confidence and performance.
How antidepressants may affect your performance
Antidepressants are prescribed to help regulate mood and relieve symptoms of depression, anxiety, and other mental health disorders. Most commonly, these medications include selective serotonin reuptake inhibitors (SSRIs) that work by increasing serotonin levels in the brain, a neurotransmitter responsible for regulating mood, sleep, and emotional stability.

While this elevation of serotonin can boost mood, it can also interfere with the intricate balance of hormones and nerve signals that control sexual desire. The same mechanisms that calm anxiety can inadvertently suppress libido, delay orgasm, and reduce erectile strength. Antidepressants may affect your performance in the following ways:
Changes in brain chemistry
Serotonin plays a crucial role in emotional well-being, but high levels can suppress dopamine, the neurotransmitter responsible for desire. When dopamine levels drop, your brain’s natural reward system is affected, making it harder to feel aroused or engaged in sexual activity.
Hormonal imbalance and testosterone suppression
Certain antidepressants can indirectly reduce testosterone levels or alter hormone signaling. Testosterone helps maintain erectile strength, stamina, and sexual drive. Even a mild imbalance can contribute to fatigue, reduced motivation, and weaker erections.
Nerve desensitization and genital numbness
Some men experience reduced sensitivity or numbness in the genital area after starting antidepressants. This occurs because serotonin affects the way nerves transmit signals, potentially dulling pleasurable sensations and making it harder to reach orgasm.
Impaired blood flow and erection quality
Erections depend on strong blood circulation to the penile tissue. Certain antidepressants can alter vascular function, limiting the ability of blood vessels to dilate. This may cause weaker or shorter-lasting erections, even when desire is present.
Emotional and psychological factors
Beyond biology, antidepressant-related sexual dysfunction can have emotional ripple effects. Frustration, lowered confidence, and performance anxiety can amplify the problem, creating a cycle that further inhibits sexual satisfaction.

How the P-Shot can help reclaim sexual vitality
The P-Shot is an innovative procedure that uses your body’s platelet-rich plasma (PRP) to help rejuvenate penile tissue, stimulate natural healing, and enhance erectile function. The treatment involves drawing a small amount of your blood, isolating the concentrated plasma rich in growth factors, and then injecting it into areas of the penis responsible for blood flow and sensitivity.
At Genesis Lifestyle Medicine, this treatment is performed by experienced medical professionals trained in regenerative medicine. The P-Shot may help address many of the same physiological and nerve-related challenges caused by antidepressant use without medication or surgery. Here’s how the P-Shot can help you reclaim sexual vitality and performance.
Restoring healthy blood flow
The growth factors within PRP stimulate the development of new blood vessels and improve circulation. This increase in blood flow can lead to firmer, longer-lasting erections, helping you regain natural erectile function that may have diminished due to medication.
Enhancing sensitivity and sensation
The P-Shot promotes nerve regeneration, which may help counter the numbness or reduced sensitivity some men experience from antidepressants. Over time, this can result in greater responsiveness and more pleasurable sensations during intimacy.
Supporting tissue regeneration and cellular repair
PRP is packed with bioactive proteins that encourage cell growth and tissue rejuvenation. When injected into penile tissue, it may help repair microvascular damage, increase elasticity, and revitalize the erectile tissue that supports strong, spontaneous erections.
Improving sexual stamina and confidence
By enhancing both blood flow and sensitivity, many men report feeling more confident and in control during sexual activity after receiving the P-Shot. This renewed performance often translates into improved intimacy, reduced anxiety, and a more positive self-image.

Complementing antidepressant treatment safely
The P-Shot is drug-free and works in harmony with your existing medical treatments. Because it uses your own plasma, there’s no risk of allergic reaction or interactions with antidepressants. This makes it a safe, natural option for men seeking to restore performance.
Reclaim performance with Genesis Lifestyle Medicine
Sexual performance is deeply tied to your sense of vitality and connection, and when antidepressants interfere, it can feel discouraging. But you don’t have to simply “live with it.” With the regenerative potential of the P-Shot, you can naturally restore what’s been lost.
At Genesis Lifestyle Medicine, we specialize in helping men address sexual health challenges with advanced, evidence-based solutions that promote whole-body balance. Our providers take a personalized approach to every treatment, ensuring your care aligns with your goals, lifestyle, and current medications. If you’re experiencing performance changes, the P-Shot may help you reclaim your vitality.


                