You may have noticed lately that your energy doesn’t carry you through the day the way it used to. Workouts that once felt invigorating now leave you sore for longer, and no matter how much you rest, fatigue lingers. Maybe your metabolism feels slower, or you’re having more difficulty focusing than you did a decade ago. These are common signs that your body’s internal chemistry is shifting as part of the natural aging process.

One of the key players behind this change is NAD+, a molecule essential for cellular energy, repair, and overall vitality. At Genesis Lifestyle Medicine, we specialize in proactive, science-backed treatments that help you take charge of aging from the inside out. In this article, you’ll learn when NAD+ supplementation is most beneficial, how to recognize the right time to begin, and what steps you can take to maximize results.

At what age should you start taking NAD+?

There’s no exact birthday when NAD+ supplementation becomes necessary, but research shows that your body’s natural NAD+ supply begins to decline noticeably by your early 30s. By your 40s, levels may already be reduced by 50%, and by the time you reach 60, NAD+ stores can be depleted by as much as 80%. This has real consequences: it slows your metabolism, weakens your ability to repair DNA, and reduces your cells’ efficiency in producing energy.

That’s why starting supplementation in your 30s is often recommended as a proactive measure. By intervening early, you can slow the rate of decline, support cellular resilience, and maintain higher energy reserves as you age. For some, supplementation may be worth considering even sooner if you’re already experiencing fatigue, brain fog, or extended recovery after exercise. At Genesis Lifestyle Medicine, we often encourage people not to wait until symptoms become overwhelming. Instead, taking NAD+ at the right time helps preserve overall wellness.

Signs indicating it’s a good time to start NAD+

Even though age is a guideline, your body will also give you clear signals when it’s time to think about NAD+ support. Understanding these signs can help you act sooner rather than later.

Persistent fatigue

If you feel exhausted despite getting adequate sleep, your cells may not be producing energy efficiently. Since NAD+ is essential for mitochondrial function, low levels often manifest as persistent fatigue. Supplementing helps restore energy at the cellular level, giving you the stamina to power through your day.

Slower workout recovery

Muscle soreness that lingers longer than it used to is another sign. NAD+ supports tissue repair, circulation, and recovery after exertion. When your NAD+ levels dip, your body struggles to heal micro-tears and inflammation as effectively. Supplementation with NAD+ can help reduce downtime and improve your performance over time.

Difficulty managing weight

Have you noticed it’s harder to maintain or lose weight, even if your diet and activity haven’t changed? NAD+ plays a role in regulating metabolism, particularly in how your body processes glucose and fat. Declines in NAD+ levels can disrupt metabolic balance, leading to slower calorie burn and weight gain. Supplementation helps restore metabolic function.

Early cognitive changes

Brain fog, trouble concentrating, or reduced memory sharpness are also linked to NAD+ depletion. Since NAD+ helps repair DNA and supports neuronal health, low levels of this molecule can contribute to mental sluggishness and a range of cognitive issues. Supplementation helps improve focus, clarity, and long-term brain resilience.

Visible signs of aging

NAD+ decline also manifests externally. If your skin appears duller, elasticity is reduced, or fine lines are appearing earlier than expected, these may be cellular-level changes that are showing through. Supporting NAD+ levels helps rejuvenate skin health by aiding in DNA repair and promoting collagen function.

Tips to optimize NAD+ outcome:

• Begin supplementation consistently in your early 30s
• Monitor for fatigue, cognitive decline, or slow recovery as signs of timing
• Combine supplementation with a balanced diet rich in antioxidants
• Stay physically active to naturally boost mitochondrial function
• Reduce alcohol and processed sugar intake to preserve NAD+ stores
• Consider advanced therapies like IV or injectable NAD+ under medical supervision
• Support NAD+ with good sleep hygiene and stress reduction practices
• Schedule regular check-ins at Genesis Lifestyle Medicine for guidance

Starting NAD+ supplementation is less about hitting a certain birthday and more about recognizing when your body is signaling the need for support. While most people benefit from starting in their 30s, signs such as fatigue, slower recovery, or cognitive decline can indicate it’s time to start earlier. By taking proactive action, you’re not just adding years to your life; you’re also adding energy, vitality, and resilience to every year.

At Genesis Lifestyle Medicine, we believe in healing from the inside out. Our expert providers are here to guide you on when and how to begin NAD+ supplementation so you can maintain peak performance and age on your own terms. Contact us today to schedule your consultation.