If you’re considering the P-Shot or have already scheduled your treatment, you may be wondering how to get the absolute best results. The P-Shot works by using your own platelet-rich plasma (PRP) to stimulate tissue repair, enhance blood flow, and support natural erectile function over time. Because the P-Shot relies on your body’s ability to heal, regenerate, and form new vascular pathways, your daily habits play a key role in its effectiveness.
Beyond maintaining a healthy lifestyle with a balanced diet and regular exercise, targeted supplements can further help with blood circulation. While supplements are not standalone treatments for erectile dysfunction, certain vitamins, minerals, amino acids, and hormonally supportive compounds may help optimize circulation, nitric oxide availability, and cellular recovery, which, in turn, can help you get the most from P-Shot.
At Genesis Lifestyle Medicine, we believe in healing from the inside out, and this article explores the best supplement pairings that can complement your P-Shot results.
Vitamin D
Vitamin D plays a key role in hormone balance, vascular function, and overall sexual wellness. Low levels of vitamin D have been associated with an increased likelihood of erectile difficulties, partly because vitamin D influences endothelial health, the lining of your blood vessels. Strong, healthy blood vessels respond better to nitric oxide, which is critical for maintaining erections.
Studies suggest that men with higher vitamin D levels tend to have higher testosterone and improved erectile function. If you’re deficient, supplementation may help you support the P-Shot’s ability to restore healthier blood flow. It’s also important to note that vitamin D works with magnesium, which means your body absorbs and uses vitamin D more effectively when magnesium levels are sufficient.
Magnesium
Magnesium is involved in hundreds of biochemical reactions, including the regulation of smooth-muscle relaxation within blood vessels. When your magnesium levels are low, your arteries can constrict, making it harder for blood to circulate efficiently. Since erections depend on strong vascular relaxation, magnesium can play a meaningful role in supporting the P-Shot.
Low magnesium levels have also been associated with increased blood pressure, reduced nitric oxide availability, and poor vascular responsiveness. If your healthcare provider has identified a deficiency, supplementing magnesium may help optimize your results.
Vitamin B3 (Niacin)
Vitamin B3 is one of the most well-studied vitamins for vascular support. Niacin promotes vasodilation, helping blood vessels widen so blood can circulate more freely. In one study, men with moderate to severe ED who took daily niacin experienced significant improvement in their ability to maintain an erection, and this effect can potentially improve the results of the P-Shot.
Because niacin supports lipid balance and reduces inflammation, it may also enhance microvascular health in the penis. However, high doses can cause side effects such as flushing, gout, or elevated liver enzymes, so it’s important to discuss niacin supplementation with your healthcare provider before starting and to do so in moderation.
Vitamin B9 (Folic Acid)
Folic acid is essential for nitric oxide production, a key mechanism behind healthy erectile function. Nitric oxide helps signal blood vessels in the penis to expand, allowing more blood to enter and stay during arousal. Some studies have shown a correlation between folate deficiency and decreased erectile response.
Because the P-Shot improves vascular integrity and stimulates healthier tissue, supporting nitric oxide pathways with folic acid may help your body respond more effectively to treatment. Foods like leafy greens, citrus fruits, beans, and whole grains are rich in folate, but supplementation may be recommended if your levels are low.
Vitamin E
Vitamin E is a powerful antioxidant that supports circulation and oxygen delivery to tissues. Since erectile function depends heavily on healthy microcirculation, vitamin E may help support the regenerative processes initiated by the P-Shot. Improved oxygenation allows tissues to heal more effectively and enhances endothelial health.
Its antioxidant effects also help reduce oxidative stress, an underlying factor in vascular dysfunction. While vitamin E shouldn’t be relied upon as an ED treatment, it can play a supportive role when used to complement evidence-based therapies like the P-Shot.
Citrulline and L-arginine
Citrulline and L-arginine are amino acids involved in nitric oxide production, which helps relax blood vessels and improve blood circulation. L-arginine directly converts to nitric oxide in the body, while citrulline is a precursor that is often better absorbed. Both have shown potential benefits in improving erections due to their vasodilatory effects.
These supplements act similarly, but more mildly, to PDE5 inhibitors by helping the penis receive more consistent blood flow. Because the P-Shot promotes vascular repair, supporting nitric oxide pathways may help you maintain stronger, more reliable erections.
DHEA
DHEA is a hormone naturally produced by the adrenal glands and acts as a precursor to testosterone and estrogen. Some men with ED have been found to have low DHEA levels, and supplementation may support healthier hormone balance. While not a standalone treatment for ED, DHEA may help improve libido and support the hormonal environment for P-Shot results.
Because hormone levels play such a crucial role in sexual performance, DHEA can be a meaningful support for men whose ED symptoms are partially related to low testosterone. However, supplementation should only be used under medical supervision.
Red ginseng
Korean red ginseng has long been studied for its potential to improve erectile function. Research suggests that it may enhance nitric oxide production, improve endothelial function, and support healthier vascular response. Many men report improved stamina, libido, and firmness when using red ginseng consistently.
Although more research is needed, red ginseng may serve as an effective natural complement to the P-Shot’s regenerative benefits, particularly for vascular-related erectile difficulties.
The P-Shot is a powerful regenerative treatment, and the right supplements may help support better blood flow, healthier tissue repair, and stronger erectile response over time.
At Genesis Lifestyle Medicine, we believe in healing from the inside out, pairing advanced medical treatments with targeted nutritional strategies to help you look, feel, and function at your absolute best. Always speak with a medical provider before starting any supplement regimen so you can safely and effectively enhance your P-Shot results.
