If you’re exploring effective weight loss treatments, you may already know about GLP-1 medications like semaglutide and tirzepatide. These therapies are helping thousands of people lose weight by regulating appetite and stabilizing blood sugar levels. However, while GLP-1s deliver impressive results, they can also come with side effects, such as fatigue, a slowed metabolism, and mental fog. NAD+ therapy can help with these side effects.

At Genesis Lifestyle Medicine, we specialize in comprehensive solutions that address your health from multiple angles. By combining NAD+ with GLP-1s, you can improve energy, protect metabolism, support brain function, and enhance outcomes. Let’s explore how this powerful pairing works and why it may help you reach your goals more effectively.

How NAD+ can help with weight management

Nicotinamide adenine dinucleotide (NAD+) is a coenzyme found in every living cell. It plays a critical role in converting the food you eat into cellular energy, repairing DNA, and regulating key metabolic processes. Unfortunately, NAD+ levels naturally decline with age, leaving you more prone to fatigue, a slower metabolism, and decreased resilience.

When you supplement with NAD+, you give your body the support it needs to function more efficiently. This impacts weight management in several ways:

• NAD+ boosts cellular energy production, helping you feel more active and motivated.
• NAD+ promotes efficient metabolism, making it easier for your body to burn calories.
• NAD+ helps reduce oxidative stress, supporting long-term health as you lose weight.

How GLP-1s promote weight loss

GLP-1 medications, including semaglutide and tirzepatide, were initially developed for type 2 diabetes but have quickly become some of the most effective tools for medical weight loss. These medications mimic your body’s natural GLP-1 hormone, which helps regulate blood sugar, slow digestion, and increase satiety. However, by reducing intense hunger and sugar cravings, GLP-1s make it easier to eat less without feeling deprived.

Beyond appetite control, GLP-1s also help improve insulin sensitivity and stabilize blood sugar, which reduces energy crashes and overeating. Many patients lose significant amounts of weight over several months, with steady progress that leads to improved cholesterol and reduced risk of cardiovascular disease. However, the treatment is not without challenges, and it can lead to side effects like fatigue, slower metabolism, and brain fog.

Optimize your results by combining NAD+ with GLP-1s

The question remains: can NAD+ really be paired with GLP-1s for better results? The answer is yes. These treatments complement each other beautifully. While GLP-1s help you eat less and lose weight, NAD+ ensures your body continues to generate energy, recover, and think clearly. Together, they enhance the weight loss experience and make it easier to stay consistent. Below, we describe the benefits of combining NAD+ with GLP-1s.

Increased energy levels

GLP-1s often reduce calorie intake, leading to sluggishness. By boosting mitochondrial energy production, NAD+ helps counteract this effect. You’ll have the stamina to stay active, exercise regularly, and maintain your daily routine without being slowed down by fatigue.

Enhanced metabolism

As you lose weight, your metabolism naturally slows down, a process that can create plateaus and discourage progress. NAD+ supports metabolic pathways at the cellular level, helping your body continue burning calories efficiently and promoting steady weight loss.

Better exercise recovery

Many people on GLP-1s become more active as the pounds drop off. But starting a new fitness routine can be tough on your muscles, leading to soreness and long recovery times. NAD+ supports tissue repair and resilience, enabling your body to adapt more quickly.

Improved cognitive function

Brain fog is a common complaint during weight loss, especially when food intake is reduced. NAD+ helps protect brain cells and supports neurotransmitter activity, improving focus, clarity, and overall mental sharpness. This ensures your mind is as sharp as your body is lean.

Support for long-term success

One of the biggest challenges of weight loss is sustaining results. By improving energy, metabolism, and mental clarity, NAD+ helps you stay consistent with your GLP-1 therapy and maintain lifestyle changes that can create a foundation for long-term health.

Pairing NAD+ therapy with GLP-1s creates a holistic approach to weight loss that addresses not just the pounds you want to lose, but also the way you feel. NAD+ therapy helps replenish your energy, sharpen your mind, and support your metabolism, while GLP-1s regulate appetite and blood sugar. Together, they make the process smoother, more effective, and more sustainable.

At Genesis Lifestyle Medicine, we believe in helping you look and feel your absolute best by combining innovative treatments with compassionate care. If you’re ready to optimize your weight loss journey and experience the benefits of pairing NAD+ with GLP-1s, our expert providers can evaluate your concerns and determine the most suitable approach for you.