Fertility is deeply tied to how well your body functions at the cellular level. Every process involved in reproduction, from hormone regulation to egg maturation, depends on your cells’ ability to generate energy, repair DNA, and communicate efficiently. Unfortunately, as you age, these cellular processes begin to slow down, leading to a natural decline in fertility.

This is where NAD+ comes in.

NAD+ (nicotinamide adenine dinucleotide) is a coenzyme present in every cell of your body that supports energy production, DNA repair, and vitality. New studies have shown that restoring NAD+ levels through personalized therapies may help improve reproductive function by enhancing egg quality, hormone balance, and mitochondrial health.

At Genesis Lifestyle Medicine, we help you optimize your natural functions through advanced, evidence-based therapies, so you can take a proactive step toward improving your fertility from the inside out. In this article, we explore how NAD+ therapy may help with fertility.

The connection between NAD+ and fertility

NAD+, or nicotinamide adenine dinucleotide, is an essential coenzyme found in every cell of the body. It acts as a cellular “helper,” assisting with metabolic functions, energy production, and DNA repair. Unfortunately, NAD+ levels decrease naturally as you age, contributing to slower cell repair, hormonal changes, and a decline in reproductive potential.

Here’s how your NAD+ levels can directly or indirectly affect your reproductive health:

Egg quality

Egg quality is one of the most important factors influencing fertility, and research shows that NAD+ plays a significant role in maintaining it. As you age, the eggs in your ovaries experience DNA damage and reduced mitochondrial activity, which lowers their quality. NAD+ supports the repair of cellular damage and helps maintain the integrity of egg DNA. Restoring NAD+ may rejuvenate older eggs, improving their viability and the likelihood of a successful pregnancy.

Hormone regulation

Hormonal balance is another key area where NAD+ makes an impact. Your reproductive hormones, including estrogen, progesterone, and luteinizing hormone, depend on cellular health and energy production to function properly. NAD+ helps regulate these processes by optimizing cell communication and supporting the endocrine system. Improved hormone regulation can help restore normal ovulation cycles and increase the chance of natural conception.

Mitochondrial function

Mitochondria are often called the “powerhouses” of the cell, producing the energy needed for nearly every biological process, including egg maturation and fertilization. NAD+ is crucial for mitochondrial performance. When NAD+ levels are low, mitochondrial energy production slows down, which can reduce the energy available for egg development. By increasing NAD+, you support more efficient mitochondrial function, leading to stronger, more resilient eggs.

Systemic health

Beyond reproductive function, NAD+ influences your overall health, indirectly benefiting your fertility and reproductive health. Higher NAD+ levels can enhance metabolism, promote better sleep, reduce inflammation, and improve cardiovascular health. These benefits contribute to a more balanced internal environment, which supports hormonal stability and increases your body’s ability to sustain a healthy pregnancy.

Can NAD+ therapy increase fertility?

Now that you understand the vital role NAD+ plays in fertility, the next question is: can therapy really make a difference? While research on human fertility and NAD+ supplementation is still evolving, early studies and clinical evidence are promising.

NAD+ therapy, offered at Genesis Lifestyle Medicine through convenient injections, patches, or nasal sprays, aims to restore your body’s natural NAD+ levels, helping your cells work more efficiently and rejuvenating your reproductive system from the inside out.

Here’s how NAD+ therapy may increase your fertility:

Improving egg quality and quantity

As women age, both the number and quality of eggs decline due to oxidative stress and mitochondrial deterioration. NAD+ therapy can help counteract these effects by enhancing DNA repair, cellular energy, and oocyte (egg) function. This may lead to improved egg health, which is especially valuable for individuals in their mid-30s and beyond who are trying to conceive.

Supporting hormone balance

NAD+ therapy may help stabilize hormonal fluctuations that often accompany aging or stress. By boosting mitochondrial activity and cellular metabolism, NAD+ encourages a more balanced hormonal environment. This can improve ovulation regularity and the function of reproductive organs, two essential factors in fertility success.

Enhancing mitochondrial performance

Since mitochondria depend heavily on NAD+ to generate energy, replenishing your NAD+ stores can enhance their function. This improvement extends to egg cells, which are particularly energy-demanding. Better mitochondrial efficiency means better egg maturation, fertilization, and embryonic development potential, all of which contribute to higher chances of conception.

Promoting whole-body wellness

Fertility isn’t just about your reproductive organs: it’s about your entire system functioning in harmony. NAD+ therapy may improve sleep quality, reduce fatigue, and boost mental clarity, all of which can lower stress. It can also support cardiovascular health and metabolism, which helps you maintain a healthy weight, which is essential for hormonal balance.

Natural ways to support NAD+ levels:

• Exercise regularly to improve mitochondrial health
• Maintain consistent sleep and wake cycles
• Eat nutrient-dense foods rich in niacin and tryptophan
• Avoid excessive alcohol consumption
• Manage stress and prioritize relaxation
• Stay hydrated to support cellular function
• Limit processed foods and refined sugars
• Follow regular meal times to stabilize your circadian rhythm

While NAD+ therapy is not a guaranteed cure for infertility, it represents an exciting and scientifically grounded approach to improving reproductive health. By supporting cellular repair, hormone regulation, and mitochondrial performance, restoring NAD+ levels may help you enhance fertility and improve your chances of conception, especially as you age.

At Genesis Lifestyle Medicine, we take a comprehensive approach to wellness that includes cellular optimization, hormone therapy, and fertility support. Our providers can help you restore balance, revitalize your body, and move closer to your goal of starting or expanding your family. Schedule your consultation to learn more about how NAD+ therapy may help you.