You may have heard about the incredible benefits of NAD+ therapy, from boosting your energy to sharpening focus and supporting healthy aging. For many people, NAD+ feels like a powerful reset button for their health, helping them reclaim vitality they thought they had lost. But like any treatment, NAD+ therapy isn’t without its potential challenges. Some people notice mild side effects as their body adjusts, particularly in the early stages of treatment.
That doesn’t mean you should shy away from it. Instead, it’s about knowing what to expect, how to prepare, and how to minimize any discomfort along the way. At Genesis Lifestyle Medicine, we provide personalized care, ensuring your NAD+ therapy is as safe and effective as possible. Let’s look at some of the most common side effects of NAD+ and how you can reduce them.
Common side effects of NAD+ therapy
NAD+ (nicotinamide adenine dinucleotide) is a vital coenzyme that helps your cells turn food into energy, repair DNA, and regulate essential functions. Because NAD+ naturally declines with age, therapy can restore these reserves and help you feel more vibrant. However, as your body adjusts to higher levels, some side effects may occur.
Nausea and stomach discomfort
One of the most frequently reported side effects is nausea, especially when NAD+ is delivered quickly through an IV infusion. This discomfort happens because your metabolism is shifting gears, increasing energy production at the cellular level. Eating a light meal before your session and slowing the infusion rate often make this effect much less noticeable.
Headaches or lightheadedness
Some patients experience headaches or a sensation of dizziness during or shortly after NAD+. This may result from temporary changes in blood flow or how your brain cells are utilizing energy. Usually, these headaches resolve quickly, especially when hydration is managed.
Flushing or a warm sensation
A common but harmless side effect is a sudden warmth or flushing in your face or body. This is often linked to the speed of IV delivery. While it can be surprising, it is not dangerous and typically fades within minutes once the infusion rate is adjusted.
Muscle cramps or mild weakness
Occasionally, NAD+ therapy can cause cramping or a feeling of muscle weakness. This is likely related to how NAD+ interacts with electrolytes and energy metabolism. Your provider may suggest supportive care such as electrolyte balance to reduce these symptoms.
Temporary fatigue
Although many patients report a long-term boost in energy, it’s possible to feel tired immediately after a session. This temporary fatigue is simply your body adjusting to the sudden cellular changes and usually improves after a good night’s sleep.
How to minimize the side effects of NAD+ therapy
The good news is that NAD+ side effects are usually short-lived and manageable. With the right approach, you can maximize the benefits while minimizing any discomfort.
Start with a slower infusion rate
One of the simplest ways to reduce side effects is to adjust the pace of NAD+ delivery. A rapid infusion may overwhelm your system, causing nausea or flushing. By starting with a slower drip rate, your body has time to adapt, making the session more comfortable.
Stay hydrated before and after treatment
Hydration plays a key role in reducing side effects like headaches or dizziness. Drinking water before and after your session helps your body process the therapy more efficiently. Some patients also benefit from electrolyte support to keep their energy levels balanced.
Eat a light meal beforehand
Coming to your session on an empty stomach may increase the chances of nausea. A light meal, such as fruit, yogurt, or whole grains, can make your treatment experience smoother while still allowing your body to absorb NAD+ effectively.
Space out your sessions appropriately
Your body may need time to adjust to NAD+ therapy, especially at the beginning. Scheduling sessions too close together can increase the risk of fatigue or digestive discomfort. Your provider at Genesis Lifestyle Medicine will design a schedule tailored to your health goals, ensuring that your body has time to respond positively.
Choose an experienced provider
The safest way to minimize side effects is by working with a trusted provider who understands how to tailor treatments to your needs. At Genesis Lifestyle Medicine, we monitor your health, adjust your dosage, and guide you through every step. This patient-centered approach helps keep side effects to a minimum while maximizing the long-term benefits of NAD+.
NAD+ therapy has the potential to transform your energy, focus, and overall wellness. While mild side effects such as nausea, flushing, or headaches can occur, they are typically temporary and manageable with the right care. At Genesis Lifestyle Medicine, our team takes the time to customize every treatment, ensuring you feel supported throughout NAD+ therapy. If you’re ready to restore your vitality, contact us to explore your options.
