When you start exploring NAD+ therapy, one of the first questions that comes to mind is, “How much NAD+ do I really need?” The truth is, there’s no one-size-fits-all answer. Your ideal NAD+ dosage depends on your health goals, current energy levels, age, and how your body responds over time. Finding the right balance is key to unlocking the full potential of this coenzyme.
At Genesis Lifestyle Medicine, NAD+ therapy is carefully tailored to your unique needs. Our medical professionals assess your health history, goals, and response to treatment to determine the most effective dosage. Whether you’re aiming for enhanced focus, youthful vitality, or faster recovery, this guide will help you understand how NAD+ dosage is determined.
What is the ideal NAD+ dosage?
Nicotinamide adenine dinucleotide (NAD+) is a vital coenzyme found in every cell of your body. It supports countless biological functions, from energy production to DNA repair. However, NAD+ levels decline with age, leading to fatigue, cognitive fog, and slower cellular repair.

There isn’t a universal “ideal” dosage for everyone, because NAD+ is highly personalized. On average, a typical injection or supplement protocol might range from 5 mg to 10 mg daily for maintenance, or 100 mg to 1,000 mg per day under clinical supervision for intensive goals. The right amount depends on what you’re treating, whether it’s age-related fatigue, brain fog, or recovery from chronic stress.
At Genesis Lifestyle Medicine, your NAD+ therapy plan is customized through consultation, allowing your provider to adjust the dose and frequency based on your overall goals, the administration method, your progress, and how your body responds to treatment.
Factors that determine the perfect NAD+ dosage
1. Your age and baseline NAD+ levels
As you get older, your natural NAD+ reserves begin to decline. This drop affects your metabolism, mitochondrial function, and ability to repair DNA. Older adults often require higher or more frequent doses to restore youthful cellular activity. A younger person may respond well to smaller doses, while someone in their 50s or 60s might need stronger or more consistent therapy to achieve noticeable results.
2. Your overall health and medical history
Chronic conditions like diabetes, inflammation, or liver disease can accelerate NAD+ depletion. Similarly, long-term stress, sleep deprivation, and poor nutrition all reduce your body’s ability to maintain healthy NAD+ levels. If you’re recovering from illness or managing underlying health issues, your dosage may need to be adjusted to safely restore cellular balance. That’s why we take your full medical background into account before creating your treatment plan.
3. Your wellness goals
The purpose behind your NAD+ therapy significantly influences dosage. For example:
- Anti-aging and longevity: Smaller, consistent doses spaced out over time.
- Cognitive enhancement: Moderate doses may be used to improve mental clarity.
- Addiction recovery: Higher doses over a short period can help restore neurotransmitter balance.

4. Your response to treatment
Everybody metabolizes NAD+ differently. Some individuals feel an immediate improvement in energy and mental clarity, while others experience gradual changes over weeks. Tracking your progress helps your provider fine-tune your dose, either increasing or reducing the amount to maintain optimal results without unwanted side effects like mild nausea or fatigue.
5. Delivery method of NAD+
NAD+ can be delivered through injections, patches, or nasal sprays, each offering different absorption rates. Injections typically deliver higher concentrations directly into your bloodstream, while nasal sprays and patches offer gentler, slower absorption. The right method depends on your comfort level, treatment goals, and how quickly you want to experience results.
Tips to optimize the results of NAD+ therapy
Once your dosage is established, adopting healthy habits can support your body and enhance the effectiveness of NAD+ therapy.
1. Eat foods that support NAD+ production
Your diet directly influences how efficiently your body maintains NAD+ levels. Incorporate foods rich in vitamin B3 (niacin), such as salmon, chicken, peanuts, mushrooms, and leafy greens. These foods provide natural NAD+ precursors, helping sustain your results between treatments.
2. Manage stress effectively
Chronic stress consumes large amounts of NAD+ as your body produces stress hormones like cortisol. By incorporating relaxation techniques, such as meditation, yoga, or deep breathing, you can preserve NAD+ levels and improve your overall cellular balance.
3. Prioritize high-quality sleep
Sleep is when your body performs essential repair and restoration processes. Poor or inconsistent sleep disrupts these functions and depletes NAD+. Aim for 7 to 8 hours of restful sleep each night to support healthy metabolism and optimal energy restoration.

4. Limit alcohol and environmental toxins
Excessive alcohol consumption and exposure to pollutants can strain your liver and deplete NAD+ reserves. Reducing alcohol intake and minimizing toxin exposure will help your therapy work more effectively by lowering oxidative stress.
5. Stay consistent with your treatment plan
Consistency is key when it comes to NAD+ therapy. Skipping sessions or stopping early can lead to diminished results. By following your customized plan from Genesis Lifestyle Medicine and attending regular check-ins, you can ensure sustained cellular rejuvenation.
Rebalance your energy and vitality with Genesis Lifestyle Medicine
Finding your perfect NAD+ dosage isn’t about hitting a single number: it’s about understanding your body and aligning treatment with your goals. With personalized guidance at Genesis Lifestyle Medicine, you can experience the benefits of NAD+ therapy safely and effectively.
From improving energy and focus to supporting anti-aging and overall wellness, NAD+ therapy offers a pathway to renewed vitality and long-term balance. Schedule your consultation today and let us help you restore your body’s natural energy from the inside out.


