When you begin exploring wellness treatments like NAD+, one of the first questions you may have is how long the results will last and how often you’ll need to continue sessions. Because NAD+ plays a central role in energy production, cellular repair, and brain health, its effects are often felt quickly; however, the duration and frequency depend on your goals and lifestyle.

At Genesis Lifestyle Medicine, we know that no two patients are the same. That’s why we take a personalized approach, guiding you through what to expect from NAD+ therapy and how to use it safely and effectively. By understanding timelines, recommended frequencies, and potential risks, you can maximize the benefits of this powerful treatment.

How long do the results of NAD+ therapy last?

The longevity of NAD+ results varies based on factors such as your age, lifestyle, and specific health conditions. While NAD+ is rapidly absorbed and put to work by your cells, its benefits extend well beyond the initial dose. Here’s what you can expect across timelines:

Immediate results (within hours to 2 days)

Right after your first session, you may begin to notice a shift in your energy and mental clarity. These effects often make NAD+ appealing to those who feel drained or mentally foggy. You can expect the following effects within 2 hours:

• Boost in alertness and focus
• Mild but noticeable energy increase
• Greater sense of calm or uplifted mood
• Reduced brain fog

Short-term results (within 1-2 weeks)

As you continue with therapy, the benefits compound. This phase is particularly helpful for those who struggle with fatigue or stress-related exhaustion. Over time, you may experience:

• Steadier, more sustainable energy levels
• Improved motivation and productivity
• Better quality of sleep
• Enhanced concentration and memory recall

Medium-term results (within 1-3 months)

Consistent use over weeks to months begins to influence deeper cellular repair and anti-aging processes. You may notice that you feel more stable and experience:

• Improved stamina due to strengthened mitochondrial function
• Reduced feelings of burnout and fatigue
• Heightened emotional balance and resilience
• Visible improvements in skin tone and vitality

Long-term results (3+ months and ongoing)

For those who commit to NAD+ therapy as part of a long-term wellness routine, the effects can be profound. These results tend to support whole-body health and healthy aging, including:

• Sustained energy and endurance
• Ongoing DNA repair and cellular protection
• Support for brain health and cognitive longevity
• Better recovery from stress, illness, or intensive physical activity

How often should you take NAD+ therapy?

The frequency of NAD+ therapy varies from person to person. It depends on your personal health goals and why you are seeking treatment. At Genesis Lifestyle Medicine, we tailor therapy schedules based on a comprehensive assessment of your needs.

For general wellness and anti-aging

If your main goal is to maintain energy, support cognitive health, and slow cellular aging, a moderate schedule is typically recommended. Receiving NAD+ once or twice a week allows your body to maintain steady levels of this coenzyme. This frequency works especially well for middle-aged or older adults who want to age gracefully, maintaining their energy levels and mental sharpness without requiring a more intensive treatment plan.

For detox, addiction recovery, or chronic fatigue

For individuals facing significant health challenges such as detoxification, addiction recovery, or chronic fatigue, NAD+ often begins with a more intensive phase. During this time, treatments may be given daily for four to ten days to quickly replenish NAD+ levels and support the body during a difficult recovery period. Once the initial phase is complete, the schedule typically transitions to weekly or monthly maintenance sessions to help sustain the benefits.

For athletic performance and recovery

Athletes and highly active individuals often turn to NAD+ therapy to enhance performance and speed up recovery. In these cases, a schedule of one to three sessions per week is common, especially during periods of intense training or after strenuous activity. By replenishing NAD+ more frequently, athletes can reduce fatigue, improve recovery times, and support muscle repair. This ensures the body recovers more effectively after being pushed to its limits.

For brain health and cognitive support

Those seeking mental clarity and long-term cognitive support may also benefit from NAD+ on a regular basis. A typical schedule for this purpose may include one or two treatments per week, which helps sharpen focus, reduce brain fog, and improve memory. Over time, as progress is made, the frequency can often be reduced while still maintaining the cognitive benefits, creating a sustainable approach to supporting brain health.

Consequences of taking NAD+ therapy too often

While NAD+ therapy is considered safe and excess NAD is naturally excreted, taking it too frequently or in doses that are too high may cause temporary discomfort. These effects are usually mild but worth considering:

• Headaches or dizziness
• Nausea, stomach upset, or cramping
• Rapid heartbeat or flushing
• Irritability or mood swings
• Muscle tightness or chest pressure

Most of these side effects can be reduced by staying hydrated, eating light meals before sessions, and resting afterward. More importantly, working with a qualified provider ensures that your therapy plan remains balanced and beneficial.

NAD+ therapy offers immediate, short-term, and long-term benefits for energy, focus, recovery, and healthy aging. The duration of results and the frequency of treatments depend entirely on your health goals and current lifestyle. At Genesis Lifestyle Medicine, we tailor your treatment plan to help you maximize the benefits of every session. By finding the right frequency and duration for you, we can help you reach your true health and wellness potential.