You may already know that NAD+ therapy supports energy, brain function, metabolism, and healthy aging, but one of the first questions you probably have is how often you should actually receive it. The short answer is that frequency depends on your body, your current health status, and what you’re trying to achieve. Some people benefit from an initial series of treatments, while others do best with occasional maintenance sessions.
At Genesis Lifestyle Medicine, NAD+ therapy is offered as part of a personalized, medically guided wellness approach that helps your body function at its best from the inside out. In this article, you’ll learn how often NAD+ therapy is typically recommended, what different schedules look like, and the key factors that influence your ideal treatment plan.
How often do you need NAD+ therapy?
NAD+ therapy is not a one-size-fits-all treatment. Your frequency will depend on whether you’re just getting started, addressing more significant symptoms, or focusing on maintenance.
For first timers
If you’re new to NAD+ therapy, your provider may recommend a short loading phase to help replenish depleted NAD+ levels. As you age, your natural NAD+ production declines, and many people begin treatment with lower-than-optimal levels. A loading phase allows your body to build up a healthier baseline more quickly.
During this phase, you may receive 1-2 sessions per week for 2-4 weeks, or approximately 2-4 total sessions within the first month. Many people notice early improvements in energy, mental clarity, sleep quality, or well-being during this period. The goal is to restore cellular NAD+, so your body can better support energy production, DNA repair, and metabolism. Once this foundation is established, your provider can determine the right long-term schedule.
For intensive support
If you’re dealing with persistent fatigue, brain fog, metabolic challenges, or signs of accelerated aging, a more frequent schedule may be appropriate at first. Intensive support plans are first formulated to address more significant imbalances and help your body stabilize.
With this approach, NAD+ therapy is often used once per week for 4-8 weeks, followed by reassessment. Many people choose this route when they want to jump-start improvements or when symptoms are interfering with life. As your body responds and your symptoms improve, frequency can often be reduced to a maintenance schedule. The emphasis is on adjusting treatment based on how you feel and how your body responds over time.
For regular maintenance
Once your NAD+ levels are more stable, most people transition to a maintenance plan. Maintenance therapy focuses on sustaining the benefits you’ve already achieved, such as steady energy, sharper focus, and improved resilience.
Maintenance sessions are typically scheduled once every 4-6 weeks, though some individuals with high stress levels or demanding lifestyles may benefit from every 3-4 weeks. This ongoing support helps counteract the natural decline of NAD+ that continues with aging and everyday stress. Think of maintenance NAD+ therapy as similar to regular exercise or healthy nutrition: it’s a proactive way to preserve function and support long-term wellness.
Factors that determine NAD+ dosage and frequency
Several personal factors influence how often you may need NAD+ therapy. A comprehensive evaluation helps your provider design a plan that aligns with your goals and physiology.
Age and natural NAD+ decline
NAD+ levels naturally decrease as you get older. This decline becomes more noticeable in adulthood and continues gradually over time. If you’re experiencing age-related changes such as reduced energy, slower recovery, or cognitive shifts, you may benefit from more consistent NAD+ support. Younger individuals may require less frequent sessions, while those further along in the aging process often need ongoing maintenance to sustain optimal levels.
Current symptoms and health concerns
Your symptoms help determine frequency. If you’re experiencing fatigue, brain fog, poor concentration, mood changes, or metabolic struggles, your provider may recommend a more structured treatment plan. People who feel generally well but want to support healthy aging and performance may only need periodic sessions. The more pronounced your symptoms, the more likely it is that a higher initial frequency will be helpful.
Lifestyle and stress levels
High-stress lifestyles, demanding jobs, frequent travel, irregular sleep, and intense physical training can increase your body’s need for NAD+. Chronic stress places a heavy burden on cellular energy systems, which may accelerate NAD+ depletion. If your routine is physically or mentally taxing, you may benefit from more frequent therapy to support recovery.
Wellness and longevity goals
Your personal goals matter. Some people pursue NAD+ therapy primarily for anti-aging and longevity support, while others focus on cognitive performance, metabolic health, or vitality. Those with more ambitious or multifaceted goals may choose a more proactive schedule. Your provider will help align frequency with what you want to achieve.
Individual response to therapy
Everyone’s body responds differently. Some people feel noticeable benefits quickly, while others experience more gradual improvements. Your response helps guide adjustments to dosage and frequency. Regular check-ins with your provider allow your plan to evolve based on real-world results, ensuring you’re receiving the right level of support without overtreatment.
Finding the right balance for your body
NAD+ therapy works best when it’s part of a personalized wellness strategy rather than a standalone solution. When combined with healthy nutrition, quality sleep, regular movement, and guidance, it can play a meaningful role in helping you feel and function better.
At Genesis Lifestyle Medicine, NAD+ therapy is integrated into a patient-centric care model that focuses on understanding your needs and creating a plan that supports long-term health. The right approach is the one that keeps you feeling energized, focused, and supported as your body changes over time. With personalized care and ongoing evaluation, NAD+ therapy can be a valuable tool in maintaining vitality and promoting healthy aging. Contact us today to schedule your consultation.
