The P-Shot is a regenerative, non-surgical treatment that uses platelet-rich plasma (PRP) to improve blood flow, stimulate tissue repair, and enhance sexual function. By injecting growth factors derived from your blood, the P-Shot promotes stronger erections, increased sensitivity, and better sexual stamina. The results are not instantaneous, but they build naturally over time as your body responds to the growth factors. For many men, the improvements can last several months, but determining exactly how long results last depends on your unique physiology.
At Genesis Lifestyle Medicine, you receive a personalized approach to sexual wellness. Your provider evaluates your goals, symptoms, and response to treatment to determine the optimal frequency for your P-Shot sessions. In this article, you’ll discover what influences your treatment schedule, how long results typically last, and how to make them last even longer.
How long do P-Shot results last?
Most men experience results that last anywhere from 6 to 12 months. Because the P-Shot stimulates natural tissue regeneration, its improvements develop gradually, typically beginning within a few weeks and continuing to strengthen over several months. You may notice better erection firmness, increased sensitivity, enhanced sexual stamina, and, in some cases, improved penile curvature if you’re dealing with Peyronie’s disease.

Your body will continue to benefit from the growth factors long after the initial session, but, as with any regenerative treatment, the effects can diminish over time. Aging, lifestyle habits, and underlying health conditions all influence how long your P-Shot benefits remain at their peak. This is why many men return for maintenance treatments every 6 to 12 months.
Key factors that determine your P-Shot frequency
Severity of erectile dysfunction
If you’re dealing with mild ED, you may experience significant benefits from a single session, with maintenance only once or twice per year. Men with advanced ED often require a series of initial treatments, typically spaced out over a few months, to fully restore blood flow and tissue health. The more severe the dysfunction, the more frequently you may need follow-ups.
Presence of Peyronie’s disease
Peyronie’s disease involves scar tissue and curvature that require ongoing regenerative support. Because PRP stimulates tissue repair and collagen remodeling, men with Peyronie’s often need additional sessions within the first few months. Follow-up treatments help reduce scar tissue, improve curvature, and enhance sexual function.
Your personal goals
Your reasons for getting the P-Shot affect how often you’ll need treatment. Some men simply want to restore natural erectile function, while others seek enhanced sensitivity, increased stamina, or improvements in girth. If you’re aiming for more dramatic sexual enhancement rather than correction, you may benefit from more frequent sessions.
Your body’s response to PRP
Every man responds differently to regenerative treatments. Some experience rapid, long-lasting improvements after a single session, while others require more stimulation to kick-start optimal tissue growth. Your provider at Genesis Lifestyle Medicine will monitor your progress and adjust your treatment plan based on your response.

Lifestyle and overall health
Your cardiovascular health, hormone balance, diet, exercise habits, and stress levels influence the longevity of your results. Conditions like diabetes, high blood pressure, and low testosterone can diminish erectile function, meaning you may need treatments more often.
Age-related changes
Because aging affects blood flow and tissue elasticity, older men may notice their results fade sooner than younger men. Regular treatment intervals, such as every 6 months, can help counteract the natural age-related decline in sexual health.
Use of complementary treatments
If you're also undergoing therapies such as TRT, shockwave therapy, or peptide optimization, these additional treatments may enhance the effects of the P-Shot and reduce how often you need follow-ups. Conversely, not addressing hormonal or vascular issues may require more frequent sessions to maintain results.
Tips to optimize the longevity of P-Shot results:
- Follow your provider’s aftercare guidelines: Your post-treatment routine plays a significant role in how effectively the growth factors stimulate tissue repair. Following instructions such as avoiding strenuous activity, using recommended devices, or performing at-home stimulation techniques can significantly extend your results.
- Maintain a heart-healthy lifestyle: Because erections depend heavily on vascular health, habits that promote strong circulation, such as regular exercise, healthy eating, and weight management, help prolong the benefits of the P-Shot. A body that supports optimal blood flow will maintain regenerative changes for much longer.
- Avoid smoking and limit alcohol: Smoking compromises blood vessels, while excessive alcohol can weaken erectile function. Eliminating or reducing these habits allows the PRP to work more effectively and helps your results last longer.

- Address underlying medical conditions: Conditions such as diabetes, high cholesterol, and hypertension affect blood circulation and can shorten the lifespan of P-Shot results. Working with your healthcare provider to manage these issues ensures you get the longest and most consistent effects from treatment.
- Optimize hormones: Low testosterone can undermine sexual function and slow tissue repair. If your hormones are unbalanced, the P-Shot may not deliver its full potential. Combining P-Shot with hormone optimization can extend your results.
- Consider maintenance sessions: Even if your initial results last a long time, regular maintenance every 6 to 12 months help reinforce improvements and prevent decline. Many men find that ongoing treatments compound the benefits over time.
The P-Shot is a powerful regenerative treatment that can significantly improve erectile function, sensitivity, and sexual performance. While the results can last up to a year, your ideal frequency depends on your goals, your health, and how your body responds to treatment.
At Genesis Lifestyle Medicine, your provider tailors your P-Shot schedule to ensure lasting, personalized results. With the right plan and healthy habits, you can maintain optimal sexual wellness, confidence, and performance for the long term.


