If you’ve recently had a P-Shot, you may notice mild swelling, firmness, or even a small lump on the injection sites. Like many of our patients at Genesis Lifestyle Medicine, you may wonder whether it’s part of the normal healing process or something to be concerned about. In most cases, mild lumpiness, swelling, and bruising are perfectly normal side effects of the P-Shot. However, understanding what’s normal, what’s not, and how to support recovery can help you get the best possible outcome from your treatment.
Are lumps normal after a P-Shot?
Yes, lumps after a P-Shot are common and, in most cases, completely normal. The P-Shot uses platelet-rich plasma (PRP) from your own blood, which is injected into targeted areas of penile tissue. When PRP is introduced, your body initiates a localized healing response. This response can include temporary swelling, firmness, or a small lump at or near the injection site.
These lumps are typically caused by a combination of mild inflammation, fluid distribution, and the tissue response to the injection. PRP contains growth factors that signal your body to repair tissue and improve blood flow. As this process begins, it’s normal for the area to feel slightly firm or uneven. In most men, these changes gradually soften and resolve within several days to a week as the PRP integrates and swelling subsides.

However, there are situations where a lump may not be considered normal. If a lump becomes increasingly painful, grows larger instead of smaller, feels unusually hard, or persists beyond a couple of weeks, it’s important to contact your provider. Severe pain, redness spreading beyond the injection site, or signs of infection are also reasons to seek prompt medical guidance. Your provider can determine if you require further evaluation.
Other normal side effects of P-Shot
In addition to lumps, there are several other short-term effects you may notice after a P-Shot. These are generally mild and temporary.
- Mild swelling or fullness: Temporary swelling is one of the most common side effects. The injected PRP and the body’s inflammatory response can cause the penis to look or feel slightly fuller for a few days before returning to baseline.
- Tenderness or sensitivity: You may experience mild soreness or increased sensitivity in your penis, particularly when touching the treated area or during early erections. This typically fades as tissue recovery progresses.
- Redness or light bruising: Small injection sites can lead to localized redness or minor bruising. This is a normal reaction to needle entry and usually resolves on its own.
- Temporary firmness: Some men notice areas that feel firmer than usual during the first week. This firmness is often associated with early healing activity and tends to soften over time.
- Subtle warmth or inflammation: Because PRP stimulates blood flow and cellular repair, a slight sensation of warmth or inflammation can occur. This is generally a reassuring sign that the treatment is activating your body’s natural repair mechanisms.

Signs that warrant an evaluation
While most post-P-Shot symptoms are benign, it’s still important to know when something may need professional attention. If symptoms persist, worsen, or feel out of proportion to what you were told to expect, it’s best to reach out to your provider. Warning signs include the following:
- Increasing pain instead of gradual improvement
- Lumps that harden or grow larger over time
- Redness that spreads beyond the injection area
- Significant warmth or skin discoloration
- Fever or flu-like symptoms
- Difficulty with urination or severe discomfort during erections
Tips to ensure optimal results from a P-Shot
Supporting your body after treatment is crucial. Simple aftercare habits can help side effects resolve more smoothly while enhancing the results:
- Give your body time to heal: Avoid sexual activity and vigorous stimulation for a few days following your P-Shot. This allows PRP to settle into the tissue and reduces irritation that can prolong swelling or lumps.
- Limit strenuous exercise initially: Heavy lifting or intense workouts can increase blood pressure and swelling at injection sites. Light movement is fine, but wait until your provider clears you to resume strenuous activity.
- Avoid smoking and excess alcohol: Smoking and alcohol impair circulation and tissue repair. Since PRP works by improving blood flow and healing, limiting these habits during recovery supports better results.

- Follow medication guidance: Certain medications, including NSAIDs and blood thinners, may increase bruising or interfere with inflammation needed for healing. Always follow your provider’s recommendations regarding medication use.
- Stay consistent with your treatment plan: Many men see the best results from a series of P-Shot treatments rather than a single session. Following the recommended schedule helps improvements build gradually and last longer.
A confident recovery with Genesis Lifestyle Medicine
In most cases, a lump after a P-Shot is simply part of your body’s normal healing response. Temporary swelling, firmness, and mild discomfort are expected as PRP improves circulation and tissue health. However, knowing what’s normal and when to check in can help you move through recovery confidently.
At Genesis Lifestyle Medicine, your care doesn’t stop after the procedure. Our team is committed to guiding you through every phase of treatment, answering questions, and ensuring your experience is safe and effective. If you’re considering a P-Shot or have questions about your recovery, schedule your consultation today.


