Pushing through a workout is one thing, and recovering from it is another. The soreness, stiffness, and fatigue that follow exercise aren’t just a sign of hard work; they’re the result of complex processes inside your cells. One essential component of these processes is NAD+ (nicotinamide adenine dinucleotide), a vital coenzyme involved in energy production and cellular repair. When your NAD+ levels are sufficient, your body becomes efficient at repairing damaged tissues, reducing inflammation, and restoring energy after strenuous activity. But as you age, these levels naturally decline, making recovery slower.
As a leader in wellness strategies that support long-term vitality, Genesis Lifestyle Medicine offers personalized NAD+ therapies to help enhance muscle recovery and improve your post-exercise results. In this article, we explore how NAD+ influences your body after exercise and what you should know to optimize your recovery.
How NAD+ may help with muscle recovery
Enhancing cellular energy production
Your muscles rely on mitochondria, the powerhouses of your cells, to produce energy. NAD+ is essential for mitochondrial function and serves as a coenzyme in energy-conversion pathways. When NAD+ levels are optimal, your cells generate energy more efficiently, giving your muscles what they need to repair themselves after workouts. By maintaining high NAD+ availability, you may experience reduced fatigue and improved endurance during future training sessions.

Supporting DNA repair after exercise
Strenuous exercise can cause microscopic tears in your muscle fibers and lead to DNA damage at the cellular level. Your body repairs this damage as part of the natural recovery process. NAD+ fuels enzymes called PARPs (poly ADP-ribose polymerases) that are responsible for repairing damaged DNA. Higher NAD+ levels help these enzymes work more efficiently, speeding up tissue repair and promoting muscle resilience.
Reducing inflammation for faster recovery
Inflammation is a normal response to exertion, but when inflammation lingers, it can result in prolonged soreness. NAD+ plays a role in regulating your body’s inflammatory response. By supporting sirtuin enzymes responsible for inflammation control, NAD+ therapy helps minimize post-workout inflammation. This may reduce pain, improve range of motion, and shorten the time needed before your next session.
Slowing the effects of aging on muscles
As you age, your NAD+ levels naturally decrease. This affects your muscles’ ability to repair quickly and regenerate. Supplementing NAD+ or engaging in practices that stimulate its production may help counteract this decline. With improved cellular resilience, aging muscles may bounce back more efficiently from strenuous exercise, helping you maintain strength and performance well into later years.
Improving mitochondrial health
Beyond energy production, NAD+ contributes to mitochondrial maintenance and the formation of new mitochondria through a process known as mitochondrial biogenesis. By supporting this system, higher NAD+ levels may increase the number of healthy mitochondria in your muscle cells. More mitochondria means better energy availability, less fatigue, and enhanced recovery from intense physical activity.

What to know after your workout
NAD+ levels may influence your soreness
Post-workout soreness is often attributed to lactic acid or muscle strain, but cellular stress and inflammation are also key contributors. If your NAD+ levels are low, your body may struggle to address these stressors efficiently, resulting in more intense soreness.
Supplement timing matters
Some research suggests that taking NAD+ precursors before or after a workout may impact how effectively your body uses this coenzyme. Post-workout supplementation may support mitochondrial repair and inflammation control when your muscles need it most.
Diet can support NAD+ production
Your body can produce NAD+ using certain nutrients found in food. Lean meats, fish, nuts, and whole grains contain niacin and other precursors needed to help your cells maintain NAD+ levels. When combined with regular exercise, a nutrient-rich diet may amplify the benefits of NAD+ supplementation and help your muscles recover faster.
Exercise itself can stimulate NAD+ levels
Your workout doesn’t just use energy; it also encourages your cells to create more NAD+. Regular physical activity may naturally increase NAD+ production, promoting better endurance and resilience over time. Think of movement as a catalyst that prepares your body to repair itself from the inside out.

NAD+ is not a substitute for balanced recovery habits
While NAD+ may assist with muscle recovery, it isn’t a stand-alone solution. Proper hydration, sleep, stretching, and rest days all contribute to recovery. Your muscles need a well-rounded approach to repair and become stronger. NAD+ works best as part of a comprehensive recovery strategy rather than as a shortcut.
Whether you’re an athlete or someone committed to improving health through fitness, understanding how NAD+ affects muscle recovery can help you get more out of every workout. By supporting energy production, DNA repair, inflammation control, and cellular resilience, NAD+ may play a pivotal role in how quickly your muscles rebound after exercise.
At Genesis Lifestyle Medicine, you can explore options that may help boost your NAD+ levels, enhance your recovery, and support better performance. Schedule your consultation today to get the most out of your workouts and work toward greater strength and vitality.


