You may have noticed that erections are less reliable than they used to be or it takes more effort to achieve or maintain firmness. Maybe pills only help sometimes, or you’re tired of planning intimacy around medications or supplements that promise results but fall short.
At Genesis Lifestyle Medicine, erectile dysfunction is approached as a whole-body issue, not just a single symptom. Two options men often compare are regenerative treatments like the P-Shot and supplements. Understanding how each option functions, what results you can expect, and which aligns best with your goals can help you make an informed decision.
Overview
P-Shot
The P-Shot, also known as the Priapus Shot, is a regenerative treatment that uses platelet-rich plasma (PRP) derived from your own blood. Platelets contain growth factors that support tissue repair, blood vessel formation, and cellular regeneration. When PRP is injected directly into the penile tissue, it targets the root causes of erectile dysfunction, such as reduced blood flow. The goal is not temporary stimulation, but long-term improvement through structural change.
At Genesis Lifestyle Medicine, the P-Shot is performed in a clinical setting using local anesthesia. The entire process typically takes under an hour. Rather than masking symptoms, the P-Shot works with your body’s natural healing mechanisms to restore function over time.
Supplements
Supplements for erectile dysfunction are widely available and usually contain ingredients like L-arginine, ginseng, zinc, maca, or herbal extracts. These compounds are intended to support blood circulation, hormone balance, or energy levels. For some men, especially those with very mild symptoms, supplements may offer modest benefits by enhancing overall wellness.
However, supplements do not directly repair damaged tissue or create new blood vessels. They rely on systemic absorption through the digestive tract, which limits the amount of the active ingredient that reaches penile tissue. Results, if they occur, are typically subtle.
How each option works in the body
P-Shot
The P-Shot delivers a concentrated dose of growth factors exactly where they are needed. Once injected, PRP stimulates angiogenesis, or the formation of new blood vessels, while also supporting healthier nerve signaling and tissue quality. Over several weeks, these changes can lead to stronger erections, improved sensitivity, and better overall sexual performance.
Because the P-Shot induces actual biological repair, the results develop gradually and tend to feel more natural. Many men report continued improvement for months as tissue regeneration progresses, rather than a sudden or artificial effect.
Supplements
Supplements work indirectly. L-arginine, for example, is a precursor to nitric oxide, which helps blood vessels relax. Other ingredients may support testosterone production or reduce fatigue. While these mechanisms can support erectile function, they depend on consistent dosing and proper absorption over extended periods, so the results are subtle at best.
Additionally, supplements must pass through the liver and systemic circulation before reaching target tissues. This significantly reduces bioavailability, which is why many men notice little to no change even after weeks of use.
Duration and consistency of results
P-Shot
One of the most significant advantages of the P-Shot is longevity. The results last 12 to 18 months, with some men maintaining benefits even longer. Because new blood vessels and healthier tissue are formed, improvements persist without daily intervention.
Supplements
Supplements only work while you are actively taking them. If you stop, any benefit disappears quickly. Even with consistent use, results tend to plateau. For men seeking a lasting solution rather than ongoing management, this can become frustrating over time.
Safety and medical oversight
P-Shot
The P-Shot uses your own blood components, which greatly reduces the risk of allergic reactions. When administered by trained medical providers, it has a strong safety profile. Mild swelling or bruising at the injection site is possible, but complications are rare. At Genesis, every patient undergoes a thorough evaluation to ensure the treatment is appropriate based on health history and goals.
Supplements
The supplement industry is not tightly regulated. Product quality, ingredient accuracy, and potency can vary widely. Some supplements may interact with blood pressure medications, heart medications, or hormone therapies. Others may contain fillers or undisclosed ingredients that increase risks. Supplements from reputable pharmacies may be safer, but efficacy can still not be guaranteed.
Cost and long-term value
P-Shot
The P-Shot requires a higher upfront investment, but its long-lasting effects often make it more cost-effective over time. One treatment can provide benefits for a year or longer, reducing the need for recurring purchases or prescriptions.
Supplements
While supplements seem inexpensive initially, the monthly costs can add up quickly. Over a year, quality products may rival or exceed the cost of a single regenerative treatment, without offering the same level of improvement.
Which works better for ED?
For men seeking meaningful, long-term improvement, the P-Shot is clearly the more effective option. It addresses the underlying vascular and tissue-related causes of erectile dysfunction rather than temporarily boosting performance. This is especially true for moderate to severe ED, age-related decline, or cases where pills and supplements have already failed.
Supplements can still play a supportive role in erectile health. When used with regenerative treatments, they may optimize circulation, energy, and overall wellness. However, they work best as a complement, not a replacement, for medical therapies like the P-Shot.
Erectile dysfunction doesn’t have to be managed indefinitely. At Genesis Lifestyle Medicine, treatment plans are built around your biology, your goals, and your long-term health. Whether you’re exploring regenerative options or looking to enhance existing results, a personalized consultation can help you choose the path that truly restores your performance.
