You may be exploring NAD+ therapy because you want more energy, sharper focus, better metabolic health, or support for healthy aging. Perhaps you have heard about its role in cellular repair and mitochondrial function, but you also wonder what the experience is actually like once treatment begins. Are there any side effects to watch for?
At Genesis Lifestyle Medicine, NAD+ therapy is approached as part of a personalized wellness strategy to support your natural processes. Knowing the potential side effects and how to manage them allows you to get the most out of your treatment.
What are the common side effects of NAD+ therapy?
NAD+ therapy works by increasing levels of nicotinamide adenine dinucleotide, a coenzyme involved in hundreds of cellular reactions related to energy production, DNA repair, and even your metabolism. Because this therapy affects many systems simultaneously, side effects can occur as your body adapts. Most are mild and temporary, but it is important to recognize them.
Nausea and digestive discomfort
One of the most commonly reported side effects is mild nausea or stomach upset. You may notice queasiness, bloating, or a reduced appetite, especially when you first begin therapy. These often occur because your metabolism is adjusting to higher NAD+ levels and shifts in cellular activity. In most cases, digestive discomfort improves as your body acclimates.
Headaches
Some people experience headaches or pressure-like sensations during the early stages of NAD+ therapy. These headaches may be related to changes in blood vessel tone or increased cellular energy demands. While typically mild, recurring or intense headaches should be discussed with your provider so your dosing or delivery method can be evaluated.
Skin flushing or warmth
A warm, flushed sensation of the face, neck, or chest may occur in some individuals. This reaction is linked to the temporary widening of blood vessels near the skin. Although it can feel uncomfortable, flushing is usually short-lived and not dangerous. If it becomes persistent or severe, it should be addressed with your medical team.
Fatigue or low energy at first
It may seem counterintuitive, but you could feel more tired before you feel more energized. As your cells adjust to new metabolic pathways, you might notice temporary fatigue or weakness. This transitional phase often resolves as your body finds a new balance.
Dizziness or lightheadedness
NAD+ therapy can influence blood pressure regulation. Some people notice brief dizziness, particularly when standing up quickly. This side effect is more likely if you already take blood pressure medications or are sensitive to shifts in circulation.
Changes in sleep patterns
You may notice temporary changes in sleep, such as vivid dreams, difficulty falling asleep, or waking more frequently. Because NAD+ plays a role in circadian rhythm regulation and brain chemistry, short-term sleep disturbances can occur as your system adapts.
Mild muscle aches or body soreness
Occasional muscle discomfort or achiness has been reported, likely related to changes in cellular repair and energy metabolism. These sensations are typically mild and short-lived.
How to manage the side effects of NAD+ therapy
Most side effects can be minimized with thoughtful planning and individualized care. Working closely with experienced providers ensures your therapy is tailored to your needs and tolerance.
- Start with an appropriate dose: Beginning at a lower dose allows your body to gradually adjust to increased NAD+ levels. Your provider can slowly titrate your dose based on your response, reducing the likelihood of uncomfortable reactions.
- Choose the right delivery method: NAD+ can be administered through patches, injections, or nasal sprays. Each option offers different absorption rates. Selecting the delivery method that best fits your lifestyle can significantly improve tolerability.
- Stay well hydrated: Adequate hydration supports circulation, detoxification, and cellular function. Drinking enough water before and during may help reduce headaches and fatigue.
- Eat balanced meals: Proper nutrition supports the metabolic processes that NAD+ affects. Consuming meals with protein, healthy fats, and carbohydrates can help stabilize blood sugar and energy levels, reducing digestive symptoms.
- Monitor your body’s response: Pay close attention to how you feel after starting therapy. Keeping a simple log of symptoms, energy levels, sleep quality, and mood can help you and your provider fine-tune your treatment plan.
- Communicate with your provider: If side effects persist or feel disruptive, let your medical team know. Adjustments to dose, timing, or delivery method can often resolve issues quickly. Ongoing communication is key to a positive experience.
- Avoid combining with unverified supplements: Adding multiple supplements at once can increase the risk of interactions and side effects. Your provider can help determine which therapies complement NAD+ safely and which may be unnecessary.
NAD+ therapy offers promising support for cellular health, energy production, and overall wellness, but understanding potential side effects is an essential part of the process. Most reactions are mild, temporary, and manageable with personalized care and guidance. At Genesis Lifestyle Medicine, NAD+ therapy is delivered as part of a comprehensive, patient-centered approach. By knowing what to watch for and working with experienced providers, you can maximize the benefits of your wellness journey. Contact us today to schedule your personalized consultation.
