You might wake up drenched in sweat, struggle to fall back asleep, and notice your patience wears thin more quickly these days. Maybe your once-reliable metabolism is slowing, your skin feels less firm, and your energy just isn’t what it used to be. These are common experiences for women entering perimenopause, a transitional phase that can feel anything but smooth.

At Genesis Lifestyle Medicine, we understand how frustrating these changes can be, especially when traditional hormone therapies aren’t an option or aren’t what you’re looking for. That’s where sermorelin comes in. This therapy offers a new, non-hormonal way to support your body through perimenopause by stimulating the natural production of growth hormone. Here’s everything you need to know about how sermorelin may help you manage perimenopause.

What is perimenopause?

Perimenopause is the transitional period leading up to menopause, when your ovaries gradually produce less estrogen, progesterone, and other hormones. It often begins in your 40s, though some women notice changes earlier or later. Perimenopause can last several years and bring with it a host of physical and emotional shifts that affect your quality of life and energy.

As your hormones fluctuate during this time, your body may send some clear and uncomfortable signals. Here are some of the most common symptoms of perimenopause:

• Irregular or heavy periods
• Sleep disturbances or night sweats
• Mood swings or irritability
• Decreased libido or vaginal dryness
• Weight gain, especially around the abdomen
• Brain fog or memory lapses
• Muscle tone or strength loss
• Dry or aging skin

How sermorelin can help with perimenopause

Sermorelin is a bioidentical peptide that acts as a growth hormone-releasing hormone (GHRH). Instead of supplying you with synthetic hormones, it stimulates your pituitary gland to naturally produce more human growth hormone (HGH). While not a replacement for estrogen or progesterone, sermorelin supports many systems that are affected during perimenopause. Here’s how sermorelin may help ease your perimenopause transition:

Support metabolism and weight management

During perimenopause, your metabolism often slows down, making it harder to maintain your weight. Sermorelin can help by increasing your lean muscle mass and supporting your body’s ability to burn fat. As HGH levels rise, your cells become more efficient at using glucose, which can help regulate blood sugar and curb fat storage. This metabolic shift may make it easier to lose weight or prevent further gain, especially when paired with regular exercise.

Improve skin elasticity and appearance

Many women experience changes in their skin during perimenopause, including thinning, dryness, and the development of fine lines and wrinkles. Growth hormone plays a critical role in stimulating collagen and elastin production, which are essential for youthful-looking skin. By boosting HGH, sermorelin may help rejuvenate your complexion and reduce signs of aging.

Enhance mood and cognitive function

Fluctuating hormone levels during perimenopause can contribute to anxiety, depression, and trouble concentrating. While sermorelin doesn’t directly alter estrogen or progesterone, it has been associated with improved mood and cognitive function. HGH may enhance GABA activity in the brain, a neurotransmitter associated with relaxation, memory, and emotional stability.

Promote deeper, more restorative sleep

Many perimenopausal women struggle with falling or staying asleep due to night sweats, anxiety, or hormonal imbalance. Growth hormone is naturally released during deep sleep, and sermorelin may help by enhancing that cycle. Better sleep can, in turn, improve mood, energy, and hormone regulation, creating a positive ripple effect in your daily life.

Increase energy and vitality

Perimenopause often brings unexplained fatigue that no amount of caffeine seems to fix. By stimulating the production of growth hormone, sermorelin can help enhance mitochondrial function, promote cellular repair, and improve energy production. Many women report a noticeable boost in physical stamina and mental clarity within a few months.

Preserve bone density

Estrogen decline during perimenopause can accelerate bone loss, increasing your risk of osteoporosis. While sermorelin doesn’t replace estrogen, HGH has been shown to support bone remodeling. By stimulating natural HGH levels, sermorelin may contribute to stronger, healthier bones, especially when combined with resistance training and calcium-rich nutrition.

Tips to manage perimenopause (with or without sermorelin):

• Prioritize high-protein meals to support muscle mass and energy
• Perform regular strength training and aerobic activity
• Get 7-9 hours of quality sleep each night
• Stay hydrated to support metabolism and skin health
• Use mindfulness or stress-reduction techniques daily
• Avoid excess caffeine, sugar, and alcohol
• Eat fiber-rich foods to support digestion and hormone clearance
• Supplement with vitamin D and magnesium, if recommended
• Work with a provider to explore HRT or non-hormonal therapies
• Schedule regular checkups to monitor bone density and cardiovascular health

Reclaim your balance with sermorelin

Perimenopause is a uniquely challenging phase, but you don’t have to go through it alone or accept discomfort as the new normal. At Genesis Lifestyle Medicine, we specialize in whole-body wellness and personalized care and offer innovative options like sermorelin to help you navigate this transition. Whether you want to improve your metabolism, sleep better, support your skin, or feel like yourself again, we help you feel empowered every step of the way.

Let Genesis Lifestyle Medicine help you reclaim your balance naturally.