You may have reached a point where things don’t feel the same during intimacy. Perhaps your erections aren’t as firm as they once were, your sensitivity has changed, or your confidence has taken a hit. Maybe pills help a little, but not consistently, leaving you unsure where to turn next.
The P-Shot can make a meaningful difference for all of these concerns. At Genesis Lifestyle Medicine, we offer this regenerative treatment that uses your body’s healing factors to support better sexual function. Yet understanding the results is only part of the story: the recovery matters just as much. What happens afterward shapes your long-term success.
This article walks you step-by-step through the P-Shot recovery period, ensuring you know what to expect, how to prepare, and how to support the best possible outcome.
Immediately after the P-Shot: The first few hours
After your procedure, you can typically return to your day right away. The P-Shot appointment usually lasts around 30 minutes, and because it uses platelet-rich plasma derived from your own blood, it avoids synthetic medications and reduces the chance of adverse reactions. You may notice mild redness, swelling, or tenderness at the injection sites. These effects are completely normal and indicate that your body is beginning the healing process.

You should avoid strenuous exercise and sexual activity for the remainder of the day. Most men feel comfortable enough to resume normal tasks, but allowing your body a brief period of rest ensures that the PRP settles into the targeted tissue properly.
The first 48 hours: Early healing responses
Within the first two days, mild swelling or bruising may appear. These changes are not signs of complications: they’re the body’s natural inflammatory response, showing that growth factors are activating cellular repair. Applying cold packs intermittently may help ease discomfort, but avoid anti-inflammatory medications like ibuprofen. They can interfere with your body’s healing cascade, slowing the regenerative effects.
Some men report heightened sensitivity during this period, while others feel no noticeable change yet. Both responses are normal. The PRP is beginning to awaken dormant tissue, stimulate blood flow, and signal your system to repair and regenerate.
One week after the P-Shot: Early improvements may begin
By the end of the first week, many men report subtle shifts, including better sensation, improved firmness, or heightened arousal. However, it’s important to remain patient. Your results don’t plateau here; this early progress is only the beginning. The regenerative factors in PRP work gradually, building momentum over the next several weeks.
During this period, light physical activity is usually fine. If your provider recommended a post-treatment pump routine, be consistent with it. Devices like vacuum pumps can help support tissue oxygenation and enhance the PRP’s effects over time.

Weeks three to six: Noticeable improvements take hold
Most men experience the most substantial changes between three and six weeks after treatment. You may notice improvements such as:
- Stronger, more reliable erections
- Increased sensitivity or pleasure
- Enhanced firmness
- Greater confidence during intimacy
This is when the underlying tissue remodels, and new blood vessels form. As the growth factors mature and strengthen penile tissue, the benefits compound. Each week may feel different, with improvements building in stages rather than all at once.
If you had hormonal imbalances, health issues affecting circulation, or lifestyle factors like smoking or chronic stress, your timeline may differ slightly. The body’s ability to regenerate tissue is affected by overall wellness and physiology.
Three to six months: Maximum results and stabilization
By this stage, you’re likely experiencing the full spectrum of benefits. The regenerative changes have matured, blood circulation has improved, and sensitivity and firmness have increased. Many men describe this as a return to a more youthful version of themselves.
Your results may continue to evolve during this window. For some, the improvements peak earlier; for others, the gains continue toward the six-month mark. Follow-up visits help your provider determine whether an additional treatment would provide further enhancement.
One year and beyond: Time to consider maintenance
The effects of the P-Shot often last 12 to 18 months, though many men enjoy the benefits longer, especially when they support their results with healthy habits. A maintenance treatment once a year is common for those who want to remain at peak performance.
If you notice gradual changes or diminishing effects, don’t wait until everything regresses. Staying proactive helps prevent setbacks in sexual performance or confidence.

Tips to optimize P-Shot recovery and longevity:
- Maintain healthy circulation: Regular exercise promotes blood flow, which supports tissue regeneration. Cardio, weight-bearing workouts, and pelvic-floor exercises can all improve erectile function. Aim for consistency rather than intensity.
- Prioritize sleep and stress management: Hormones balance and tissues repair while you sleep. Chronic stress, poor sleep, and overwork weaken circulation and slow recovery. Creating routines that promote rest will enhance your results.
- Reduce smoking and alcohol consumption: Nicotine constricts blood vessels, and alcohol undermines sexual responsiveness. Cutting back allows your regenerative tissues to thrive and helps maintain erectile function.
- Follow provider recommendations consistently: If advised to use a penile pump, adhere to the routine. These mechanical exercises support tissue health and amplify PRP benefits. Skipping steps can diminish long-term gains.
At Genesis Lifestyle Medicine, we guide you through each stage of your P-Shot, ensuring you receive treatment that aligns with your goals and supports tangible improvements in sexual performance and overall well-being. With the right habits and consistent follow-through, your investment can deliver vitality and satisfaction for months and even years to come.


