You’re tired all the time, even after a full night’s sleep. Your skin feels dry, your thoughts feel slower, and no matter how much you exercise, the number on the scale doesn’t budge. You might brush these off as stress, aging, or lack of sleep, but what if it’s your thyroid?

Hypothyroidism, or an underactive thyroid, is more common than many people realize. And if you’ve been struggling with low energy, weight gain, or brain fog, it’s worth taking a closer look.

At Genesis Lifestyle Medicine, we help you identify the root cause of your symptoms and offer innovative solutions, like sermorelin therapy, to support your thyroid, metabolism, and overall wellness. In this article, we’ll explore what hypothyroidism really is, what signs to look for, and how sermorelin may help your thyroid function better.

What is hypothyroidism?

Hypothyroidism is a medical condition where your thyroid gland doesn’t produce enough thyroid hormones: primarily T3 (triiodothyronine) and T4 (thyroxine). These are essential for regulating your metabolism, energy production, temperature control, and even heart rate.

The thyroid gland sits at the front of your neck and is controlled by your brain’s pituitary gland, which sends a signal in the form of TSH (thyroid-stimulating hormone). When your thyroid doesn’t produce enough T3 and T4, the pituitary ramps up TSH production in an effort to stimulate it. This is why high TSH and low T3/T4 levels are often signs of hypothyroidism.

Hypothyroidism can develop slowly and often goes unnoticed in the early stages. Over time, though, it can lead to significant changes in how you feel and function. These are some of the common signs & symptoms of hypothyroidism:

• Feeling tired even after a full night’s rest
• Unexplained weight gain or difficulty losing weight
• Dry, flaky skin
• Depression or low mood
• Constipation
• Sensitivity to cold temperatures
• Slow heart rate
• Brain fog or memory issues
• Thinning hair or hair loss
• Puffy face or swelling
• Irregular or heavy menstrual periods
• Muscle weakness or aches
• Joint pain or stiffness
• Hoarse voice
• Swelling in the neck (possible goiter)

How can sermorelin help your thyroid?

Sermorelin is a growth hormone-releasing hormone (GHRH) analog, meaning it stimulates your body to produce more of its human growth hormone (HGH). While sermorelin is most commonly known for boosting energy, muscle tone, and fat metabolism, its indirect effects on thyroid health are increasingly gaining attention. At Genesis Lifestyle Medicine, we often use sermorelin as part of a broader strategy to support metabolic function. Here's how it can help:

Support thyroid hormone conversion

One of the biggest challenges in hypothyroidism is poor conversion of T4 to T3. T3 is the active form of thyroid hormone that affects your cells, but many people, even those with “normal” labs, struggle with this conversion. Hormone therapy like sermorelin can help enhance mitochondrial function and improve cellular health, which plays a crucial role in the enzymatic conversion of T4 to T3. As your cells become more efficient, your thyroid hormone metabolism improves.

Boost metabolism and energy

Both growth hormone and thyroid hormone play key roles in regulating metabolism. Low levels of either can result in fatigue, weight gain, and sluggishness. Sermorelin stimulates the release of HGH, which in turn increases IGF-1 (Insulin-like Growth Factor 1), a hormone that complements thyroid activity by enhancing metabolism and energy production. With this synergistic boost, your body becomes better equipped to burn fat, build lean muscle, and maintain a healthy weight, especially when thyroid function is underperforming.

Enhance recovery and support adrenal function

Many people with hypothyroidism also experience adrenal fatigue, especially if they’ve been under chronic stress. Growth hormone has restorative effects on the adrenal glands and the nervous system, helping the body recover from fatigue and adapt to physical or emotional stress more effectively. By supporting adrenal health, sermorelin indirectly benefits the hypothalamic-pituitary-thyroid (HPT) axis, helping to stabilize hormone output across multiple systems.

Improve sleep and overall hormone balance

Sleep is one of the most important factors in thyroid health. Poor sleep suppresses growth hormone and disrupts thyroid function. Sermorelin helps by improving deep, restorative sleep, which in turn supports hormone regulation. When you sleep better, your HGH levels increase naturally, and your thyroid has the opportunity to rest, reset, and restore hormonal balance.

Feel like yourself again with Genesis

At Genesis Lifestyle Medicine, we don’t just treat symptoms; we look at the full picture. If you’ve been told your thyroid labs are “normal” but still feel off, it may be time for a deeper evaluation.

Our providers conduct comprehensive hormone testing, including free T3, free T4, TSH, reverse T3, and IGF-1, to uncover the root cause of your symptoms. If sermorelin is right for you, we’ll customize a treatment plan to help you optimize your thyroid function, restore energy, and reclaim your metabolism. If you’re ready to explore sermorelin therapy, contact us today.