Erectile dysfunction can be deeply frustrating, especially when you take proactive steps to improve it and don’t see immediate results. The P-Shot® (Priapus Shot) is a regenerative treatment that uses platelet-rich plasma (PRP) from your own blood to stimulate tissue repair, improve blood flow, and support healthier erectile function. Because it works by activating your healing processes, the results are not instant. Some men notice subtle changes within a few weeks, while others may need several months for improvements to develop.
That waiting period can be challenging, and it may even make you question whether the treatment is working for you. At Genesis Lifestyle Medicine, our patients often ask what to do when results feel delayed or incomplete. This article explains why the P-Shot may not seem effective at first, how to recognize when it truly isn’t working, and what you can do about it.
Why the P-Shot may not seem to be working
A lack of immediate results doesn’t automatically mean failure. Several factors influence how your body responds to PRP therapy, and many are outside the treatment itself. Below, we highlight some possible reasons your P-Shot may not seem to be working.
Your body needs time to regenerate
The P-Shot does not force an erection or deliver medication that works overnight. Instead, PRP releases growth factors that stimulate blood vessel formation, tissue repair, and nerve support. These biological processes unfold gradually. For many men, noticeable improvements develop between 6 and 12 weeks, with continued progress beyond that window.
Underlying health conditions affect outcomes
Conditions such as diabetes, high blood pressure, cardiovascular disease, or high cholesterol can limit blood circulation to erectile tissue. Even with PRP stimulation, poor circulation can slow or blunt results. Hormonal imbalances, particularly low testosterone, may also interfere with sexual performance and responsiveness to regenerative treatments.
Severity and duration of erectile dysfunction matter
Men with mild or moderate ED often respond faster than those with severe erectile dysfunction. If ED has been present for many years, structural changes in the penile tissue may require multiple therapies or repeated treatments to see meaningful improvement.
Lifestyle factors can limit healing
Smoking, excessive alcohol use, chronic stress, poor sleep, and sedentary habits reduce your body’s ability to heal. Because the P-Shot relies on your own regenerative capacity, these factors can significantly influence results, even if the procedure itself was done correctly.
Variations in PRP preparation and technique
Not all PRP is the same. The platelet concentration, preparation method, and technique affect the amount of regenerative signaling that reaches the tissue. Differences in protocol can impact outcomes, which is why experience and medical oversight matter.
Signs that your P-Shot is actually not working
Some uncertainty is normal early on, but after enough time has passed, certain signs may suggest the treatment isn’t delivering the results you need. If you’re unsure, it helps to evaluate your progress objectively. After several months, you may begin to notice patterns that indicate limited response. These include:
- No improvement in erection firmness or ability to maintain erections after 8-12 weeks
- Persistent difficulty achieving erections despite sexual stimulation
- No change in sensitivity, stamina, or overall sexual confidence
- Continued symptoms related to Peyronie’s disease, such as curvature or tightness
- Minimal benefit even when lifestyle factors and general health are optimized
These signs don’t mean you’re out of options. They simply indicate that a different or more comprehensive approach may be necessary to address your erectile concerns.
What to do if P-Shot doesn’t work
If your results aren’t meeting expectations, the most important step is not giving up. Erectile dysfunction is often multifactorial, and addressing it may require a broader treatment plan. Below, we describe what you can do next if P-Shot truly doesn’t work.
Schedule a follow-up evaluation
A follow-up allows your provider to review how your body responded, assess your overall health, and determine whether adjustments are needed. This may include reviewing hormone levels, cardiovascular risk factors, or whether additional sessions are needed.
Address hormone imbalances
Low testosterone can significantly impact libido, erection quality, and response to regenerative therapies. Optimizing hormone levels through testosterone therapy may help improve sexual function on its own and enhance the effects of treatments like the P-Shot.
Consider combination therapies
Many men see better outcomes when PRP is paired with other treatments. Shockwave therapy, for example, can further stimulate blood vessel growth and improve blood circulation. Oral ED medications or other sexual health therapies may also support better results.
Improve circulation and overall health
Targeted lifestyle changes can dramatically influence erectile function. Regular exercise, improved nutrition, better sleep, stress management, and smoking cessation all support vascular health. These changes don’t just improve sexual performance; they enhance the effectiveness of any medical treatment you pursue.
Not seeing the results you hoped for after a P-Shot can be discouraging, but it isn’t the end of the road. Erectile dysfunction is complex, and successful treatment often requires patience, expert guidance, and a tailored approach that looks beyond a single procedure.
At Genesis Lifestyle Medicine, we offer comprehensive care that addresses sexual health from multiple angles. With advanced treatments and thorough evaluation and support, we help you identify the most effective treatment and regain confidence in your sexual health. Schedule your personalized consultation today!
