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Zepbound® Weight Loss in Indianapolis

At Genesis Lifestyle Medicine in Indianapolis, we offer in-person prescriptions for Zepbound® (tirzepatide) as part of our medically supervised weight loss programs. This innovative medication targets metabolic processes to assist individuals in their weight management journey. Each patient’s care plan is customized by our medical team to promote realistic, long-term wellness.

A Non-Surgical Approach to Significant Weight Loss

Zepbound is an FDA-approved injectable medication designed for adults with obesity or those who are overweight with at least one related health condition. By simulating natural gut hormones, Zepbound may help reduce appetite, increase satiety, and assist with blood sugar control. When paired with a reduced-calorie diet and more physical activity, some individuals may experience weight loss of up to 20% of their body weight.*

At our Indianapolis clinic, we perform thorough health assessments in person to determine if Zepbound is a good fit for your unique needs.

Potential Benefits of Zepbound

Patients prescribed Zepbound in Indianapolis may experience several metabolic and appetite-related benefits, including:

  • Appetite suppression and fewer cravings
  • Potential for meaningful, ongoing weight loss
  • Hormonal regulation that supports metabolic balance
  • Greater satiety after meals
  • Assistance in managing blood glucose and insulin levels
  • Possible reduction in cardiovascular and diabetic risk factors
  • FDA-approved and clinically tested
  • Prescribed in person by our experienced Indianapolis-based providers
  • Delivered through a once-weekly self-administered injection
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Understanding Zepbound’s Side Effects

Some individuals may experience mild to moderate side effects, such as nausea, constipation, vomiting, indigestion, or stomach discomfort. Reactions at the injection site, fatigue, allergic symptoms, gas, hair thinning, or heartburn have also been reported.

Zepbound should not be used by individuals who have a personal or family history of medullary thyroid carcinoma (MTC) or who have been diagnosed with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2). For comprehensive safety guidance, visit Zepbound’s official prescribing information.

How Zepbound Works for Weight Loss

Zepbound functions by activating two hormonal pathways—GLP-1 and GIP—that naturally influence appetite and digestion. These hormones send signals to the brain that promote feelings of fullness, slow the emptying of the stomach, and help stabilize blood sugar levels.

For many patients, this combination leads to reduced hunger and smaller portion sizes, both of which may contribute to weight loss. Zepbound also supports improved insulin sensitivity and blood glucose control, especially for individuals who may be prediabetic or insulin resistant.

Your Journey with Zepbound in Indianapolis

When you visit Genesis Lifestyle Medicine in Indianapolis, we begin with a thorough health screening and goal-setting session. If Zepbound is prescribed, you’ll be shown how to use the once-weekly injectable pen, which is typically administered in the abdomen or thigh.

Doses are introduced gradually to minimize side effects and support your body’s response. Throughout your program, our local providers remain available to support and adjust your plan as needed.

Does Insurance Cover Zepbound?

Coverage for Zepbound may vary depending on your insurance provider. Some private insurance companies and Medicare plans offer partial or full coverage, often requiring prior authorization. Our Indianapolis staff can help clarify your eligibility and explore available options.

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You May Be Eligible for Zepbound If You:

  • Have a body mass index (BMI) of 30 or above
  • Have a BMI of 27 or above with a related condition like type 2 diabetes
  • Face challenges losing weight through conventional means
  • Want a non-invasive alternative to surgery
  • Are committed to healthy lifestyle changes
  • Have no history of certain thyroid cancers

Clinical Evidence on Zepbound Weight Loss

Research trials have shown that Zepbound can help facilitate meaningful weight reduction when used alongside healthy lifestyle habits.

In a 72-week clinical study, participants without diabetes reported the following average results:

  • 15% (34 lbs) reduction on a 5 mg dose
  • 19.5% (44 lbs) on 10 mg
  • 20.9% (48 lbs) on 15 mg

Those receiving a placebo experienced a 3.1% (7 lbs) loss.* Individual outcomes can differ, and your provider will help assess what’s realistic based on your health profile.

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Zepbound FAQs

When will I see results?

Most individuals begin noticing weight loss within the first few weeks. More visible changes often develop between weeks 8–12 when the medication is consistently paired with proper nutrition and activity.

Is it safe?

Zepbound has been shown to be effective and is FDA-approved. While many patients tolerate it well, side effects are possible. Our Indianapolis team monitors you throughout your treatment to help you navigate any concerns. Be sure to report any bothersome or persistent symptoms to your provider.

How is it taken?

Zepbound is administered once weekly using a prefilled pen. You’ll alternate injection sites between areas like the thigh, abdomen, or upper arm.

What if I forget a dose?

If you miss your dose, try to take it within four days. If more than four days have passed, skip the missed dose and resume your normal schedule. Do not inject two doses within three days of each other.

Start Your Weight Loss Journey in Indianapolis

At Genesis Lifestyle Medicine in Indianapolis, we’re here to help you explore Zepbound as part of a larger, holistic weight loss strategy. Our providers will guide you from your first consultation through every stage of your journey with tailored support, medical oversight, and a focus on lasting wellness.

Schedule your consultation today to learn if Zepbound is right for your needs.

*Individual results vary. In a 72-week Zepbound (tirzepatide) study of adults without diabetes, average weight loss was 15.0% (34 lbs.) for 5 mg, 19.5% (44 lbs) for 10 mg, 20.9% (48 lbs.) for 15 mg, and 3.1% (7 lbs.) for placebo. In a 72-week Zepbound (tirzepatide) study of adults with diabetes, average weight loss was 12.8% (28 lbs.) for 10 mg, 14.7% (33 lbs.) for 15 mg, and 3.2% (7 lbs.) for placebo.

Jastreboff AM, Aronne LJ, Ahmad NN, Wharton S, Connery L, Alves B, Kiyosue A, Zhang S, Liu B, Bunck MC, Stefanski A; SURMOUNT-1 Investigators. Tirzepatide Once Weekly for the Treatment of Obesity. N Engl J Med. 2022 Jul 21;387(3):205-216. doi: 10.1056/NEJMoa2206038. Epub 2022 Jun 4. https://pubmed.ncbi.nlm.nih.gov/35658024

The information provided on this website is not a substitute for professional medical advice. Always consult with a qualified healthcare provider for any questions about your health or treatment.

Zepbound® is a registered trademark of Eli Lilly and Company. This website is not affiliated with, endorsed by, or sponsored by Eli Lilly and Company. All trademarks and brand names are property of their respective owners. Use of these names, logos, and brands does not imply endorsement Genesis Lifestyle Medicine. Information about Zepbound is sourced from publicly available materials and is intended for educational and informational purposes only. All rights to such content belong to the respective company.

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