If you’re dealing with erectile dysfunction (ED), you may find yourself weighing your options every time intimacy becomes stressful. Maybe you’ve noticed you’re not getting as firm as you used to, or you’re struggling to maintain an erection long enough for satisfying sex. Perhaps medications like Viagra or Cialis aren’t giving you the results you hoped for, or the side effects are becoming too disruptive.
Two of the most effective solutions for ED are P-Shot and Trimix injections, both of which can help improve sexual function in different ways. At Genesis Lifestyle Medicine, we offer both ED treatments and help you understand your choices clearly so you can make an informed decision based on your body, your goals, and your long-term wellbeing. This article breaks down the differences between the two so you know what to expect from each approach.
Overview
P-Shot
The P-Shot uses platelet-rich plasma (PRP) derived from your own blood to stimulate natural regeneration within the erectile tissue. By concentrating your platelets and injecting them into precise areas of the penis, the P-Shot delivers growth factors that encourage improved blood circulation, tissue repair, and enhanced nerve sensitivity.
Rather than producing an erection on demand, this treatment gradually strengthens erectile function over time. Many men choose the P-Shot because it supports long-term improvements with minimal side effects, and results can last several months after the initial treatment series.
Trimix
Trimix is a compounded injectable made from three vasodilators: papaverine, phentolamine, and alprostadil. When injected into the penis, these ingredients work to instantly increase blood flow, producing an erection strong enough for intercourse, often within minutes.
Trimix is typically used when oral medications are ineffective or when a man needs a reliable, on-demand solution just before sex. Its effects last about an hour, and the dosage can be adjusted to achieve the desired firmness and duration.
How each treatment works
P-Shot
The P-Shot starts with a simple blood draw. Your blood is spun in a centrifuge to separate and concentrate platelet-rich plasma. Once the PRP is ready, it’s injected into targeted areas of the penis, specifically those responsible for erectile strength and sensation.
The growth factors inside PRP stimulate biological repair, enhance circulation, and may even promote the growth of new blood vessels. Because it uses your own cells, the P-Shot is low-risk and biocompatible. Any improvements typically appear gradually over several weeks as your tissues respond to the regenerative signals.
Trimix
Trimix works pharmacologically. Each ingredient plays a different role, and together they relax smooth muscle, open the blood vessels, and draw blood into the erectile chambers. Once injected, an erection develops quickly without requiring sexual stimulation.
Because the medication acts directly on local tissue, Trimix bypasses many of the metabolic factors that cause oral medications to fail. While highly effective, Trimix does not create long-term improvements; instead, it offers immediate, temporary results.
Expected timeline of results
P-Shot
You may not see changes right away. Most men begin noticing improvements in erectile firmness, sensitivity, and responsiveness within a few weeks.
Because the P-Shot relies on biological processes such as tissue regeneration and vascular repair, the improvements build gradually. Many men experience continued enhancement for several months and choose maintenance sessions every 6 to 12 months to sustain results.
Trimix
Trimix works within minutes. Once you determine the proper dosage with your provider, it becomes a predictable, on-demand solution for sexual activity. However, the effects last only for the duration of the medication, typically about an hour, and do not accumulate over time.
Side effects and safety
P-Shot
Because PRP is drawn from your own blood, the risk of adverse reactions is very low. The most common side effects include temporary soreness or mild bruising at the injection sites. There are no systemic side effects, and the treatment is safe for most men.
Trimix
Trimix is generally safe when used correctly, but it carries more potential side effects than the P-Shot. Some men experience pain, bruising, or a small amount of bleeding at the injection site. Rarely, prolonged erections (priapism) or scar tissue formation can occur with improper use or dosing. Working closely with an experienced provider is essential to preventing complications.
Convenience and treatment frequency
P-Shot
The P-Shot involves far fewer treatments. Many men undergo an initial series of sessions, followed by maintenance as needed. Because its effects last months, it appeals to men who want long-term improvement without the need to inject before every sexual encounter.
Trimix
Trimix must be administered before each use, which makes it more time-sensitive. Some men don’t mind the routine, while others prefer a solution that doesn’t require planning. Over time, dosage adjustments may be needed to maintain consistent results.
Verdict: What’s the best ED treatment for me?
P-Shot
The P-Shot is ideal if you want a regenerative, long-term solution that enhances your body’s natural ability to achieve erections. It’s a great fit for men looking to improve overall performance, sensitivity, and tissue health while avoiding frequent medication use.
Trimix
Trimix is better suited for men who want immediate, reliable erections, especially when other treatments haven’t worked. It delivers results quickly and predictably, making it a strong option for men with moderate to severe ED.
Both treatments have an important place in modern men’s sexual health. Trimix offers fast, dependable results, while the P-Shot gradually promotes long-term improvement and stronger erections from the inside out. Many men even find that a combination approach works best: Trimix for instant confidence and the P-Shot for restoring healthier erectile function.
At Genesis Lifestyle Medicine, we help you choose the treatment that aligns with your goals, lifestyle, and desired outcomes. If you’re ready to take control of your sexual health, our team is here to guide you and help you find the right treatment.
