If you’ve been feeling chronically fatigued, gaining weight despite a healthy lifestyle, or noticing a drop in muscle tone, you may be experiencing symptoms of low growth hormone levels. As we age, the production of growth hormone declines, leading to physical and metabolic changes that affect our energy, appearance, and overall wellness.

Sermorelin therapy, a treatment that stimulates your body's own growth hormone production, can help you restore vitality, improve sleep, and rebuild strength. But to see real results, proper usage matters. How and where you inject sermorelin can significantly impact its absorption, effectiveness, potential side effects, and even the final outcomes.

At Genesis Lifestyle Medicine, we guide our patients through every step of the process to ensure optimal results with sermorelin. In this guide, we’ll walk you through exactly where to inject sermorelin and how to administer it correctly for optimal results.

Where should sermorelin be injected?

Sermorelin is administered via subcutaneous injection, which means it should be injected into the fatty tissue just beneath the skin, not into the muscle. Choosing the right site helps ensure the medication is absorbed steadily and reduces the risk of irritation or bruising.

Subcutaneous tissue is found in several areas of the body, but only certain spots are ideal for routine self-injection due to access and tissue density. It’s important to rotate injection sites regularly to prevent skin irritation and ensure consistent hormone absorption.

Here's where to inject sermorelin for best results:

• Abdomen: Inject at least one inch away from the belly button. This site offers a large surface area and is convenient for daily injections.
• Outer thigh: The upper outer portion of your thigh is easily accessible and contains sufficient fatty tissue for subcutaneous injections.
• Upper arm: The outer back portion of the upper arm can be used, though it may require assistance from someone else as it’s hard to reach.
• Buttocks: The upper outer quadrant of the buttocks is also a suitable site, particularly for those who are comfortable with this area or have caregiver support.

How to inject sermorelin for the best results?

Sermorelin is typically injected once daily before bedtime to align with your body’s natural growth hormone cycle. It must be taken on an empty stomach, ideally at least 2 hours after eating and 30 minutes before your next meal or snack, to avoid interference with absorption. Administering the injection correctly ensures that the peptide reaches your bloodstream while minimizing discomfort or complications.

Below are essential tips to help you inject sermorelin safely and successfully:

• Wash your hands and gather all supplies: Start with clean hands to prevent infection. You’ll need your sermorelin vial, a sterile syringe and needle (usually an insulin syringe), alcohol swabs, and a sharps container for safe disposal. Keeping these items organized and ready before each injection can simplify your routine.
• Prepare the medication properly: If you are using reconstituted sermorelin, ensure it's fully dissolved before drawing the dose into the vial. Gently swirl the vial; do not shake. Clean the rubber stopper with an alcohol swab before inserting the needle to draw up the prescribed amount (typically around 0.2 to 0.3 mg). Use a small-volume syringe for accurate dosing.
• Clean the injection site thoroughly: Use an alcohol swab to disinfect the chosen injection site. Let it air-dry completely to prevent stinging. Clean skin reduces the risk of infection.
• Pinch the skin and insert the needle at a 45-degree angle: Using your thumb and forefinger, gently pinch a fold of skin. Insert the needle into the fold at a 45-degree angle to reach the subcutaneous layer without penetrating muscle. Slowly depress the plunger to inject the medication, then carefully withdraw the needle.
• Rotate your injection sites: Avoid injecting in the same spot every time. Use a rotation chart or a simple journal to track where you inject each day. Repeated injections in the same location can lead to skin irritation, scarring, or reduced absorption.
• Dispose of needles safely: Immediately discard used syringes and needles in a proper sharps container. Never reuse or share needles, even with close family members. Safe disposal protects you and others from accidental injury or infection.

Additional tips to optimize sermorelin results:

• Take sermorelin at night before bed on an empty stomach
• Avoid eating for 30 minutes after your injection
• Store sermorelin in the refrigerator between 36°F to 46°F (2°C to 8°C)
• Protect the vial from direct light exposure
• Discard any unused medication 28 days after the vial is first opened
• Keep track of your injection sites to ensure proper rotation
• Maintain a consistent sleep schedule to support hormone cycles
• Incorporate strength training and cardio to amplify results
• Prioritize whole-food nutrition and adequate protein intake
• Stay hydrated to support metabolic and cellular health
• Inform your provider about any side effects or medication changes
• Schedule regular check-ins with Genesis Lifestyle Medicine for dose adjustments

Get the most from your sermorelin therapy

Sermorelin offers a safe and powerful way to restore natural growth hormone production and combat the symptoms of hormonal decline. But like any hormone therapy treatment, its success depends on how well you follow the protocol. From selecting the right injection site to maintaining a consistent schedule, each step you take can move you closer to the results you want.

At Genesis Lifestyle Medicine, our team is here to ensure you understand every part of your treatment and feel confident in your self-care. Whether you’re just starting out or looking to fine-tune your routine, we’re committed to helping you get the most from your treatments. Contact us today to get started.