Aging is a natural part of life, but the changes it brings can be challenging. Energy levels drop, hormones fluctuate, skin loses elasticity, and even cognitive sharpness can waver. Much of this is linked to the decline of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in every cell of your body that’s essential for energy production, DNA repair, and cellular function.

This has led many women to ask: could boosting NAD+ help them feel and function better? At Genesis Lifestyle Medicine, we address health from the inside out, giving your body the tools it needs to restore balance and vitality. In this article, we explore the benefits of NAD+ therapy for women, the possible side effects, and practical tips for optimizing results.

Benefits of NAD+ therapy for women

NAD+ plays a vital role in how your body produces energy, repairs damage, and regulates essential processes. For women, maintaining healthy NAD+ levels may influence multiple aspects of health, from reproductive wellness to bone density and mood.

Fertility and reproductive health

As women age, NAD+ levels in reproductive tissues, including the ovaries, naturally decline. This reduction can impact egg quality, ovulation rates, and overall fertility. Supplementing with NAD+ can improve mitochondrial function in eggs, enhance ovulation, and support healthier reproductive cell energy. Women with conditions like polycystic ovary syndrome (PCOS) may also benefit from improved ovarian function and more regular cycles.

Relief from menopausal symptoms

Perimenopause and menopause can bring disruptive symptoms, from hot flashes and night sweats to mood swings and brain fog. Because NAD+ therapy supports cellular energy and helps regulate metabolism, restoring optimal levels during this time may help reduce these symptoms. Some women report better sleep, improved cognitive clarity, and more stable moods, making NAD+ therapy a promising tool for hormonal balance.

Better bone health

Estrogen loss after menopause accelerates bone breakdown, increasing the risk of osteoporosis. NAD+ appears to support bone-building cells and slow down the rate of bone loss by maintaining healthy bone remodeling, the balance between breaking down old bone and forming new bone. This could help support bone density as women age.

Improved skin health

Skin changes are one of the most visible signs of aging, and declining NAD+ levels play a role. NAD+ fuels sirtuin enzymes that help repair DNA, protect against UV damage, and maintain skin structure. With optimal NAD+ support, you may notice improved skin texture, more even tone, and better elasticity, keeping your skin healthier from the inside out.

Mood balance and mental well-being

NAD+ helps regulate neurotransmitters and supplies brain cells with the energy they need to function. Low NAD+ can contribute to mood imbalances, anxiety, and cognitive decline. By restoring NAD+ levels, therapy may help stabilize mood, sharpen mental clarity, and enhance resilience against stress, which are the key factors for overall quality of life.

Energy and metabolism boost

One of the most consistent benefits women notice with NAD+ therapy is a sustained boost in energy. NAD+ powers your mitochondria, the tiny energy factories inside your cells, supporting endurance, metabolism, and even insulin sensitivity. For women in midlife or beyond, this can mean renewed vitality and better metabolic health.

Potential side effects of NAD+ therapy for women

Overall, NAD+ therapy is considered safe for most healthy adults when used as recommended as a wellness treatment. Side effects are typically mild and temporary. Because NAD+ influences cellular activity across the body, some women may experience temporary discomfort during or after therapy. These effects usually resolve as your body adapts. Possible side effects include:

• Diarrhea
• Nausea
• Rashes
• Hot flashes
• Leg cramps

These side effects can be managed by starting with an appropriate dose and working closely with a healthcare provider, especially if you have underlying health conditions or are pregnant, breastfeeding, or have a history of cancer or autoimmune disease.

Tips to optimize results and mitigate side effects:

• Start with the lowest effective dose recommended by your provider
• Stay well-hydrated before and after each treatment
• Eat a balanced diet rich in NAD+ precursors, such as lean proteins and leafy greens
• Engage in regular moderate exercise to naturally support NAD+ production
• Prioritize quality sleep to enhance cellular repair processes
• Manage stress with relaxation techniques like meditation or deep breathing
• Limit alcohol consumption to reduce NAD+ depletion
• Monitor your body’s response and report any unusual symptoms to your provider
• Schedule consistent sessions for steady NAD+ support

Who may benefit most from NAD+ therapy

The best candidates for NAD+ therapy include:

• Women experiencing perimenopause or menopause symptoms
• Those with age-related declines in energy, focus, or mood
• Women seeking fertility support, particularly with egg quality
• Postmenopausal women concerned about bone density or metabolism
• Those with early signs of age-related cognitive changes
• Women looking for proactive cellular health optimization

Should women take NAD+?

If you want to address age-related changes in energy, hormone balance, skin health, or cognitive performance, NAD+ therapy may be worth considering. The strongest research supports its use for fertility and menopausal symptom relief, but emerging studies suggest broader benefits for bone health, mood, and metabolic wellness.

At Genesis Lifestyle Medicine, we tailor NAD+ therapy to your unique needs, life stage, and health goals. By starting with a comprehensive evaluation and, if appropriate, lab testing, we can create a safe plan to help you feel revitalized, inside and out. If you’re ready to explore NAD+ therapy, schedule your consultation and take the first step toward renewed vitality.