At Genesis Lifestyle Medicine, we understand that mental and physical well-being are intricately connected. While antidepressants play a crucial role in managing depression and anxiety, they can also impact various aspects of your life, including sexual performance. Understanding these effects is essential for managing your overall health. In this article, we explore the various ways different types of antidepressants can affect male sexual performance and erectile dysfunction (ED) and offer practical solutions to regain your vitality.

Selective serotonin reuptake inhibitors (SSRIs)

SSRIs, including sertraline (Zoloft), fluoxetine (Prozac), citalopram (Celexa), and paroxetine (Paxil), are prescribed for depression and anxiety. These medications work by increasing serotonin levels in the brain, which can improve mood but also interfere with sexual function. The increased serotonin levels can lead to reduced libido, delayed ejaculation, and difficulties in achieving or maintaining an erection. Paroxetine, in particular, has been shown to affect up to 76% of users, making it one of the SSRIs with the highest risk of sexual side effects.

Serotonin and norepinephrine reuptake inhibitors (SNRIs)

SNRIs, such as venlafaxine (Effexor XR) and duloxetine (Cymbalta), treat both depression and anxiety by affecting serotonin and norepinephrine levels. These medications can also manage nerve pain. However, like SSRIs, SNRIs are associated with sexual side effects, impacting up to 70% of users. These side effects include decreased libido, erectile dysfunction, and delayed ejaculation. If you’re experiencing these symptoms, discuss them with your provider. There may be alternative medications or adjunct treatments to mitigate the side effects.

Benzodiazepines

Benzodiazepines, such as alprazolam (Xanax) and lorazepam (Ativan), are prescribed for anxiety and panic disorders. They work by calming the brain but can also interfere with sexual performance. These medications can cause muscle relaxation and sedation, leading to difficulties with sexual arousal and performance. Men who take benzodiazepines are two to three times more likely to experience ED. If benzodiazepines are necessary for your anxiety management, your healthcare provider can explore strategies to reduce their impact.

Antipsychotics

Antipsychotic medications are used to treat conditions like schizophrenia and bipolar disorder. These medications work by blocking dopamine, a neurotransmitter that is crucial for sexual arousal. As such