How GLP-1–Based Medications Work
GLP-1–based medications, including tirzepatide, act on hormonal pathways associated with appetite regulation and glucose metabolism. Tirzepatide interacts with both GLP-1 and GIP receptors, two incretin hormones involved in the body’s response to food intake.
These pathways play roles in signaling fullness, influencing insulin and glucagon activity, and supporting post-meal blood sugar regulation. By acting on these receptors, GLP-1–based therapies may influence appetite-related signaling and digestive processes in some individuals. The degree and nature of these effects vary and represent only one component of a comprehensive, medically supervised wellness approach that may also include nutritional guidance, physical activity, and behavioral support.
Individual responses differ, and no specific changes in appetite, weight, or metabolic measures can be guaranteed.
