You’ve probably noticed how your body feels when inflammation takes over: the stiffness in your joints, the constant fatigue, or that lingering sense of discomfort that just won’t fade. While short-term inflammation is your body’s way of healing from injury or infection, chronic inflammation can slowly wear down your health, contributing to fatigue, pain, and even heart disease.

At Genesis Lifestyle Medicine, we believe in addressing these problems at the root by supporting your body’s natural ability to repair and restore balance. That’s where NAD+ therapy comes in. By replenishing your body’s stores of nicotinamide adenine dinucleotide (NAD+), this powerful treatment helps reduce inflammation, boost cellular repair, and enhance overall vitality. Let’s explore how NAD+ therapy can help you achieve whole-body wellness and protect your health from the damaging effects of chronic inflammation.

Activating sirtuins to calm the inflammatory response

One of the most significant anti-inflammatory effects of NAD+ therapy lies in its ability to activate a family of proteins called sirtuins, the enzymes that regulate cellular repair. Sirtuins depend on NAD+ to function, meaning their activity declines as NAD+ levels drop with age.

By restoring NAD+ levels, you reactivate these critical enzymes. Sirtuins, particularly SIRT1, help inhibit NF-κB, a key protein complex that triggers inflammation in the body. When NF-κB is overactive, it promotes the release of inflammatory cytokines that can contribute to chronic conditions like arthritis, diabetes, and cardiovascular disease. Boosting NAD+ levels can help “switch off” this pathway, leading to a calmer immune response and less overall inflammation.

In other words, NAD+ therapy doesn’t just mask symptoms: it helps your body regulate inflammation at the molecular level, keeping your immune system in balance.

Reducing oxidative stress for cellular protection

Inflammation and oxidative stress are deeply interconnected. When your body is exposed to toxins, poor diet, stress, or lack of sleep, it produces reactive oxygen species (ROS), unstable molecules that damage cells and tissues. This oxidative stress triggers even more inflammation, creating a vicious cycle of cellular damage.

NAD+ plays a vital role in breaking that cycle. It contributes to the production of NADPH, a molecule responsible for regenerating antioxidants that neutralize ROS. By increasing NAD+ availability, your body strengthens its internal antioxidant defense system. This helps reduce the oxidative damage that drives inflammation and accelerates aging.

Over time, NAD+ therapy supports a more resilient cellular environment that’s better equipped to fight oxidative stress, recover from damage, and maintain long-term health.

Supporting mitochondrial health to prevent inflammatory triggers

Your mitochondria, often called the “powerhouses” of your cells, generate the energy your body needs to function. However, when mitochondria become damaged or sluggish, they can release inflammatory signals that activate the immune system unnecessarily.

NAD+ therapy revitalizes mitochondrial performance by restoring the cellular energy cycle. NAD+ acts as a coenzyme in cellular respiration, helping convert nutrients into energy. With improved mitochondrial function, cells can produce energy without inflammation.

Healthy mitochondria also reduce the release of harmful byproducts that can cause oxidative stress. As a result, NAD+ therapy promotes not just more energy, but also a state of metabolic calm, where your cells work efficiently without unnecessary immune activation.

Enhancing DNA repair and preventing inflammatory damage

Chronic inflammation often begins when your body’s cellular repair systems can’t keep up with damage from aging, toxins, or stress. Damaged DNA can send distress signals that activate immune responses, creating ongoing inflammation that accelerates tissue breakdown.

NAD+ is essential for the enzymes responsible for DNA repair, such as PARPs (poly ADP-ribose polymerases). These enzymes use NAD+ to identify and repair DNA breaks, maintaining the integrity of your genetic material. When NAD+ levels are low, DNA repair slows, and cellular damage accumulates, fueling inflammation and accelerating aging.

By replenishing NAD+ levels, you enhance your body’s ability to restore DNA structure, reduce cellular stress, and minimize the inflammatory signals caused by damage. This process not only promotes longevity but also helps protect against degenerative and autoimmune conditions.

Balancing the immune system for healthy aging

Your immune system is your body’s first line of defense, but when it becomes overactive, it can start to harm rather than protect. Chronic low-grade inflammation, known as inflammaging, is one of the main factors driving age-related diseases.

NAD+ therapy helps restore immune balance by improving communication between immune cells and reducing excessive cytokine production. It supports regulatory T-cells, the cells responsible for keeping inflammation under control, and prevents the overactivation of immune pathways that damage healthy tissues.

The result is a more harmonious immune response, where your body can effectively fight infections and heal without tipping into chronic inflammation. This balanced state supports graceful aging, increased vitality, and long-term wellness.

Promoting longevity through cellular rejuvenation

The anti-inflammatory effects of NAD+ therapy go hand in hand with its longevity-promoting benefits. Chronic inflammation is one of the primary contributors to aging and many of its associated conditions, from metabolic disorders to cognitive decline.

By reducing inflammation and improving mitochondrial function, NAD+ therapy helps your cells operate at their peak. The combination of better energy production, enhanced DNA repair, and regulated immune activity creates the foundation for optimal health as you age.

Many patients report feeling more energetic, mentally clear, and physically resilient after restoring their NAD+ levels, all signs of improved cellular vitality.

Experience the benefits at Genesis Lifestyle Medicine

At Genesis Lifestyle Medicine, our goal is to help you heal from the inside out. NAD+ therapy is one of our most advanced regenerative treatments formulated to restore cellular balance, reduce chronic inflammation, and promote longevity.

If you’ve been struggling with fatigue, inflammation, or age-related decline, NAD+ therapy may help you regain control over your health and feel revitalized from the inside out. Schedule a consultation to explore your NAD+ candidacy and restore whole-body wellness.