TriMix's mechanism of action revolves around its three key components: alprostadil, papaverine, and phentolamine. When these medications are combined, they create a potent solution for erectile dysfunction (ED). Alprostadil, a prostaglandin E1 analogue, relaxes smooth muscle cells within the blood vessels of the penis, leading to vasodilation. This dilation increases blood flow into the erectile tissues, promoting an erection.
Papaverine acts as a vasodilator by inhibiting the breakdown of cyclic adenosine monophosphate (cAMP), a molecule that relaxes smooth muscle cells, further enhancing blood flow. Lastly, phentolamine plays a role in preventing vasoconstriction, ensuring that the penile blood vessels remain dilated to maintain the erection. This combination of actions improves blood circulation to the penis, helping men achieve and sustain erections.